Psoralen as an interstrand DNA crosslinker in the selection of DNA-Encoded dynamic chemical library.

DNA-encoded chemical library (DEL) has emerged as a powerful technology for ligand discovery in biomedical research. Recently, we have developed a DNA-encoded dynamic library (DEDL) approach by incorporating the concept of dynamic combinatorial library (DCL) with DELs.

DEDL has shown excellent potential in ligand discovery towards a variety of protein targets. However, the requirement of having a pair of unnatural p-stilbazoles as the interstrand DNA crosslinker has limited the chemical diversity of DEDLs. Here, we replaced p-stilbazole with psoralen (PS) and tested the feasibility of psoralen as the crosslinker in DEDL selection.

Since psoralen is commercially available and does not require any special crosslinking partner, existing DELs may be directly used to create high-diversity DEDLs. This study is expected to greatly facilitate the development of DEDLs as a versatile tool in drug discovery.

KT 5720

B9002-.25 250 µg
EUR 483.00

KT 5720

B9002-.5 500 µg
EUR 818.00

KT 5823

20-abx076629
  • EUR 356.00
  • EUR 829.00
  • 100 ug
  • 500 ug
  • Shipped within 5-12 working days.

KT 5823

B6673-.05 50 µg
EUR 123.00

KT 5823

B6673-.1 100 µg
EUR 190.00

KT 5823

B6673-.25 250 µg
EUR 361.00

PST- KT

PVT11358 2 ug
EUR 370.00

Plasminogen Receptor (KT) (PLGRKT) Antibody

20-abx318476
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

KT 5823 (PKG kinase inhibitor)

SIH-458-100UG 100 µg
EUR 205.00
  • KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
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Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)

SIH-458-500UG 500 µg
EUR 569.00
  • KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
  • Show more
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

GA-E0451RT-48T 48T
EUR 317.00

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

GA-E0451RT-96T 96T
EUR 496.00

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

QY-E11201 96T
EUR 361.00

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

QY-E20317 96T
EUR 361.00

Factor XI Antibody Pair

55R-FAC11-KT 5 plates
EUR 745.00
Description: Factor XI antigen Matched Pair antibody Set for ELISA

Factor IX Antibody Pair

55R-FAC9-KT 5 plates
EUR 760.00
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set

55R-FIBRINO-KT set
EUR 833.00
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

Mouse RANKL ELISA Kit

55R-MRANKL-KT 1 kit
EUR 658.00
Description: ELISA kit for detection of Mouse RANKL in the research laboratory

VWF Antibody Pair

55R-VWF-KT 5 plates
EUR 775.00
Description: VWF antigen Matched Pair antibody Set for ELISA