Hotspots, recurrently mutated DNA positions in cancer, are thought to be oncogenic drivers because random chance is unlikely and the knowledge of clear examples of oncogenic hotspots in genes like BRAF, IDH1, KRAS and NRAS among many other genes. Hotspots are attractive because provide opportunities for biomedical research and novel treatments.
Nevertheless, recent evidence, such as DNA hairpins for APOBEC3A, suggests that a considerable fraction of hotspots seem to be passengers rather than drivers. To document hotspots, the database HotSpotsAnnotations is proposed. For this, a statistical model was implemented to detect putative hotspots, which was applied to TCGA cancer datasets covering 33 cancer types, 10 182 patients and 3 175 929 mutations.
Then, genes and hotspots were annotated by two published methods (APOBEC3A hairpins and dN/dS ratio) that may inform and warn researchers about possible false functional hotspots. Moreover, manual annotation from users can be added and shared. From the 23 198 detected as possible hotspots, 4435 were selected after false discovery rate correction and minimum mutation count. From these, 305 were annotated as likely for APOBEC3A whereas 442 were annotated as unlikely. To date, this is the first database dedicated to annotating hotspots for possible false functional hotspots.
KT 5720 |
B9002-.1 |
ApexBio |
100 µg |
EUR 232 |
KT 5720 |
B9002-.25 |
ApexBio |
250 µg |
EUR 483 |
KT 5720 |
B9002-.5 |
ApexBio |
500 µg |
EUR 818 |
KT 5823 |
B6673-.05 |
ApexBio |
50 µg |
EUR 123 |
KT 5823 |
B6673-.1 |
ApexBio |
100 µg |
EUR 190 |
KT 5823 |
B6673-.25 |
ApexBio |
250 µg |
EUR 361 |
CI-1040 (PD184352) |
E1KS1020 |
EnoGene |
5mg |
EUR 325 |
PD184352 (CI-1040) |
A1792-100 |
ApexBio |
100 mg |
EUR 595 |
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1] |
PD184352 (CI-1040) |
A1792-25 |
ApexBio |
25 mg |
EUR 258 |
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1] |
PD184352 (CI-1040) |
A1792-5 |
ApexBio |
5 mg |
EUR 108 |
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1] |
PD184352 (CI-1040) |
A1792-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1] |
Mouse C-Reactive Protein (CRP) ELISA Kit, 96 tests, Quantitative |
1040 |
Alpha Diagnostics |
1 kit |
EUR 773 |
Polyclonal PER2 Antibody (aa1029-1040) |
APR09040G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PER2 (aa1029-1040). This antibody is tested and proven to work in the following applications: |
Plasminogen Receptor (KT) (PLGRKT) Antibody |
20-abx318476 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
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100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
KT 5823 (PKG kinase inhibitor) |
SIH-458-100UG |
Stressmarq |
100 µg |
EUR 205 |
|
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml). |
KT 5823 (PKG kinase inhibitor) |
SIH-458-500UG |
Stressmarq |
500 µg |
EUR 569 |
|
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml). |
Recombinant Candida Albicans SET1 Protein (aa 1-1040) |
VAng-Lsx05943-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Candida Albicans (strain SC5314 / ATCC MYA-2876) Histone-lysine N-methyltransferase, H3 lysine-4 specific, recombinant protein. |
Recombinant Shigella Sonnei mdtB Protein (aa 1-1040) |
VAng-Lsx09858-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Shigella Sonnei (strain Ss046) Multidrug resistance protein MdtB, recombinant protein. |
Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt |
GA-E0451RT-48T |
GenAsia Biotech |
48T |
EUR 317 |
Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt |
GA-E0451RT-96T |
GenAsia Biotech |
96T |
EUR 496 |
MBP antibody (Prediluted for IHC) |
75R-1040 |
Fitzgerald |
7 ml |
EUR 187 |
Description: Rabbit polyclonal MBP antibody (Prediluted for IHC) |
Buprenorphine-BSA |
80-1040 |
Fitzgerald |
1 mg |
EUR 136 |
Description: Conjugated Buprenorphine-BSA hapten |
IPP1 protein (His tag) |
80R-1040 |
Fitzgerald |
100 ug |
EUR 305 |
Description: Purified recombinant Human IPP1 protein |
Alpha 2 Macroglobulin protein |
30-1040 |
Fitzgerald |
1 mg |
EUR 284 |
Description: Purified native Human Alpha 2 Macroglobulin protein |
PEX3 antibody |
70R-1040 |
Fitzgerald |
100 ug |
EUR 377 |
Description: Rabbit polyclonal PEX3 antibody raised against the N terminal of PEX3 |
DDX47 Blocking Peptide |
33R-1040 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of WIPF2 antibody, catalog no. 70R-4505 |
Mouse Ig fraction |
31R-1040 |
Fitzgerald |
10 mg |
EUR 150 |
Description: Purified Mouse Ig fraction for use as a control or blocking reagent |
Goat anti Human IgG + IgA + IgM |
41R-1040 |
Fitzgerald |
1 mg |
EUR 144 |
Description: Goat anti Human IgG + IgA + IgM secondary antibody |
Canine Factor VIII Antibody Pair |
55R-1040 |
Fitzgerald |
4 plates |
EUR 899 |
Description: Canine Factor VIII antigen Matched Pair antibody Set for ELISA |
Chicken anti Goat IgG (H + L) (biotin) |
43R-1040 |
Fitzgerald |
500 ug |
EUR 207 |
Description: Chicken anti Goat IgG (H + L) secondary antibody (biotin) |
Anti-p38 beta |
DB-1040 |
DB Biotech |
100 tests |
EUR 474 |
Piggy? Tube Rotator, including rotisserie for 42 x 0.5mL~0.8mL tubes, 2/pk, 50 x 1.5mL~2.0mL tubes, 2/pk, rotisserie for 14 x 5mL~7mL tubes, 2/pk, rotisserie for 14 x 10mL~15mL tubes, 2/pk, rotisserie for 6 x 50mL tubs, 1/pk |
ACT-1040 |
ACTGene |
|
EUR 707 |
Mouse C-Reactive Protein (CRP) reference serum (~1 ug/ml) |
1040-RS |
Alpha Diagnostics |
1 ml |
EUR 202 |
MethylFlash Urine 5-Methylcytosine (5-mC) Quantification Kit (Fluorometric) |
P-1040 |
EpiGentek |
96 Assays |
EUR 788.05 |
Description: The best epigenetics products |
Histone H3K79me1 Monomethyl Peptide |
R-1040 |
EpiGentek |
200 µl |
EUR 442.95 |
Description: kits suitable for this type of research |
Angiotensin II Acetate (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe; 1046.18) |
PP-1040 |
Alpha Diagnostics |
Bulk |
Ask for price |
Recombinant Mouse (E.Coli) GRO-beta/MIP-2 (CXCL2) |
RP-1040 |
Alpha Diagnostics |
5 ug |
EUR 164 |
Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain Sb227) |
VAng-Lsx09209-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Shigella Boydii serotype 4 (strain Sb227) Multidrug resistance protein MdtB, recombinant protein. |
Recombinant Klebsiella Pneumoniae mdtB Protein (aa 1-1040) (strain 342) |
VAng-Cr5077-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 3830 |
Description: Klebsiella Pneumoniae (strain 342) Multidrug resistance protein MdtB (mdtB), recombinant protein. |
Factor XI Antibody Pair |
55R-FAC11-KT |
Fitzgerald |
5 plates |
EUR 745 |
Description: Factor XI antigen Matched Pair antibody Set for ELISA |
Factor IX Antibody Pair |
55R-FAC9-KT |
Fitzgerald |
5 plates |
EUR 760 |
Description: Factor IX antigen Matched Pair antibody Set for ELISA |
Fibrinogen Matched Pair antibody Set |
55R-FIBRINO-KT |
Fitzgerald |
set |
EUR 833 |
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory |
Mouse RANKL ELISA Kit |
55R-MRANKL-KT |
Fitzgerald |
1 kit |
EUR 658 |
Description: ELISA kit for detection of Mouse RANKL in the research laboratory |
VWF Antibody Pair |
55R-VWF-KT |
Fitzgerald |
5 plates |
EUR 775 |
Description: VWF antigen Matched Pair antibody Set for ELISA |
Human 8-iso prostaglandin,8-iso-PG ELISA Kit |
201-12-1040 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Magnetic platform, includes 4 metal mounting strips, accessory for Piggy? Tube Rotator |
ACT-1040-6 |
ACTGene |
|
EUR 297 |
Anti-EGFR (Panitumumab)-SMCC-DM1 ADC |
ADC-W-1040 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody conjugated via a SMCC linker to DM1 |
Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain CDC 3083-94 / BS512) |
VAng-Lsx08698-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 3830 |
Description: Shigella Boydii serotype 18 (strain CDC 3083-94 / BS512) Multidrug resistance protein MdtB, recombinant protein. |
Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain CDC 3083-94 / BS512) |
VAng-Lsx08698-1mgYeast |
Creative Biolabs |
1 mg (Yeast) |
EUR 5095 |
Description: Shigella Boydii serotype 18 (strain CDC 3083-94 / BS512) Multidrug resistance protein MdtB, recombinant protein. |
Recombinant Klebsiella Pneumoniae mdtB Protein (aa 1-1040) (strain ATCC 700721 / MGH 78578) |
VAng-Cr5078-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 3830 |
Description: Klebsiella Pneumoniae (strain ATCC 700721 / MGH 78578) Multidrug resistance protein MdtB (mdtB), recombinant protein. |