HotSpotAnnotations-a database for hotspot mutations and annotations in cancer.

Hotspots, recurrently mutated DNA positions in cancer, are thought to be oncogenic drivers because random chance is unlikely and the knowledge of clear examples of oncogenic hotspots in genes like BRAF, IDH1, KRAS and NRAS among many other genes. Hotspots are attractive because provide opportunities for biomedical research and novel treatments.

Nevertheless, recent evidence, such as DNA hairpins for APOBEC3A, suggests that a considerable fraction of hotspots seem to be passengers rather than drivers. To document hotspots, the database HotSpotsAnnotations is proposed. For this, a statistical model was implemented to detect putative hotspots, which was applied to TCGA cancer datasets covering 33 cancer types, 10 182 patients and 3 175 929 mutations.

Then, genes and hotspots were annotated by two published methods (APOBEC3A hairpins and dN/dS ratio) that may inform and warn researchers about possible false functional hotspots. Moreover, manual annotation from users can be added and shared. From the 23 198 detected as possible hotspots, 4435 were selected after false discovery rate correction and minimum mutation count. From these, 305 were annotated as likely for APOBEC3A whereas 442 were annotated as unlikely. To date, this is the first database dedicated to annotating hotspots for possible false functional hotspots.

KT 5720
B9002-.1 100 µg
EUR 232.00

KT 5720
B9002-.25 250 µg
EUR 483.00

KT 5720
B9002-.5 500 µg
EUR 818.00

KT 5823
B6673-.05 50 µg
EUR 123.00

KT 5823
B6673-.1 100 µg
EUR 190.00

KT 5823
B6673-.25 250 µg
EUR 361.00

PST- KT
PVT11358 2 ug
EUR 370.00

CI-1040
HY-50295 50mg
EUR 422.00

PD184352 (CI-1040)
A1792-100 100 mg
EUR 595.00
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1]

PD184352 (CI-1040)
A1792-25 25 mg
EUR 258.00
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1]

PD184352 (CI-1040)
A1792-5 5 mg
EUR 108.00
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1]

PD184352 (CI-1040)
A1792-5.1 10 mM (in 1mL DMSO)
EUR 113.00
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1]

DS-1040 (Tosylate)
HY-101918 10mM/1mL
EUR 403.00

CI-1040 (PD184352)
E1KS1020 5mg
EUR 325.00

Mouse C-Reactive Protein (CRP) ELISA Kit, 96 tests, Quantitative
1040 1 kit
EUR 773.00

Plasminogen Receptor (KT) (PLGRKT) Antibody
20-abx318476
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

KT 5823 (PKG kinase inhibitor)
SIH-458-100UG 100 µg
EUR 205.00
  • KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
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Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)
SIH-458-500UG 500 µg
EUR 569.00
  • KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
  • Show more
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

Polyclonal PER2 Antibody (aa1029-1040)
APR09040G 0.05mg
EUR 484.00
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PER2 (aa1029-1040). This antibody is tested and proven to work in the following applications:

pLL3.7-CXCR4 shRNA (1040-1058) Plasmid
PVTB00187-4c 2 ug
EUR 356.00

Recombinant Candida Albicans SET1 Protein (aa 1-1040)
VAng-Lsx05943-inquire inquire Ask for price
Description: Candida Albicans (strain SC5314 / ATCC MYA-2876) Histone-lysine N-methyltransferase, H3 lysine-4 specific, recombinant protein.

Recombinant Shigella Sonnei mdtB Protein (aa 1-1040)
VAng-Lsx09858-inquire inquire Ask for price
Description: Shigella Sonnei (strain Ss046) Multidrug resistance protein MdtB, recombinant protein.

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-48T 48T
EUR 317.00

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-96T 96T
EUR 496.00

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E20317 96T
EUR 361.00

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E11201 96T
EUR 361.00

Mouse C-Reactive Protein (CRP) reference serum (~1 ug/ml)
1040-RS 1 ml
EUR 202.00

Chicken anti Goat IgG (H + L) (biotin)
43R-1040 500 ug
EUR 207.00
Description: Chicken anti Goat IgG (H + L) secondary antibody (biotin)

Goat anti Human IgG + IgA + IgM
41R-1040 1 mg
EUR 144.00
Description: Goat anti Human IgG + IgA + IgM secondary antibody

Canine Factor VIII Antibody Pair
55R-1040 4 plates
EUR 899.00
Description: Canine Factor VIII antigen Matched Pair antibody Set for ELISA

MBP antibody (Prediluted for IHC)
75R-1040 7 ml
EUR 187.00
Description: Rabbit polyclonal MBP antibody (Prediluted for IHC)

Buprenorphine-BSA
80-1040 1 mg
EUR 136.00
Description: Conjugated Buprenorphine-BSA hapten

IPP1 protein (His tag)
80R-1040 100 ug
EUR 305.00
Description: Purified recombinant Human IPP1 protein

Piggy? Tube Rotator, including rotisserie for 42 x 0.5mL~0.8mL tubes, 2/pk, 50 x 1.5mL~2.0mL tubes, 2/pk, rotisserie for 14 x 5mL~7mL tubes, 2/pk, rotisserie for 14 x 10mL~15mL tubes, 2/pk, rotisserie for 6 x 50mL tubs, 1/pk
ACT-1040
EUR 707.00

Alpha 2 Macroglobulin protein
30-1040 1 mg
EUR 284.00
Description: Purified native Human Alpha 2 Macroglobulin protein

Mouse Ig fraction
31R-1040 10 mg
EUR 150.00
Description: Purified Mouse Ig fraction for use as a control or blocking reagent

DDX47 Blocking Peptide
33R-1040 100 ug
EUR 180.00
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of WIPF2 antibody, catalog no. 70R-4505

PEX3 antibody
70R-1040 100 ug
EUR 377.00
Description: Rabbit polyclonal PEX3 antibody raised against the N terminal of PEX3

Recombinant Mouse (E.Coli) GRO-beta/MIP-2 (CXCL2)
RP-1040 5 ug
EUR 164.00

Histone H3K79me1 Monomethyl Peptide
R-1040 200 µl
EUR 442.95
Description: kits suitable for this type of research

MethylFlash Urine 5-Methylcytosine (5-mC) Quantification Kit (Fluorometric)
P-1040 96 Assays
EUR 788.05
Description: The best epigenetics products

Angiotensin II Acetate (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe; 1046.18)
PP-1040 Bulk Ask for price

Anti-p38 beta
DB-1040 100 tests
EUR 474.00

Recombinant Klebsiella Pneumoniae mdtB Protein (aa 1-1040) (strain 342)
VAng-Cr5077-1mgEcoli 1 mg (E. coli)
EUR 3830.00
Description: Klebsiella Pneumoniae (strain 342) Multidrug resistance protein MdtB (mdtB), recombinant protein.

Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain Sb227)
VAng-Lsx09209-inquire inquire Ask for price
Description: Shigella Boydii serotype 4 (strain Sb227) Multidrug resistance protein MdtB, recombinant protein.

Factor XI Antibody Pair
55R-FAC11-KT 5 plates
EUR 745.00
Description: Factor XI antigen Matched Pair antibody Set for ELISA

Factor IX Antibody Pair
55R-FAC9-KT 5 plates
EUR 760.00
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set
55R-FIBRINO-KT set
EUR 833.00
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

Mouse RANKL ELISA Kit
55R-MRANKL-KT 1 kit
EUR 658.00
Description: ELISA kit for detection of Mouse RANKL in the research laboratory

VWF Antibody Pair
55R-VWF-KT 5 plates
EUR 775.00
Description: VWF antigen Matched Pair antibody Set for ELISA

Recombinant Klebsiella Pneumoniae mdtB Protein (aa 1-1040) (strain ATCC 700721 / MGH 78578)
VAng-Cr5078-1mgEcoli 1 mg (E. coli)
EUR 3830.00
Description: Klebsiella Pneumoniae (strain ATCC 700721 / MGH 78578) Multidrug resistance protein MdtB (mdtB), recombinant protein.

Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain CDC 3083-94 / BS512)
VAng-Lsx08698-1mgEcoli 1 mg (E. coli)
EUR 3830.00
Description: Shigella Boydii serotype 18 (strain CDC 3083-94 / BS512) Multidrug resistance protein MdtB, recombinant protein.

Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain CDC 3083-94 / BS512)
VAng-Lsx08698-1mgYeast 1 mg (Yeast)
EUR 5095.00
Description: Shigella Boydii serotype 18 (strain CDC 3083-94 / BS512) Multidrug resistance protein MdtB, recombinant protein.

Magnetic platform, includes 4 metal mounting strips, accessory for Piggy? Tube Rotator
ACT-1040-6
EUR 297.00

Human 8-iso prostaglandin,8-iso-PG ELISA Kit
201-12-1040 96 tests
EUR 440.00
  • This 8-iso prostaglandin ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Anti-EGFR (Panitumumab)-SMCC-DM1 ADC
ADC-W-1040 1mg Ask for price
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody conjugated via a SMCC linker to DM1