HotSpotAnnotations-a database for hotspot mutations and annotations in cancer.

Hotspots, recurrently mutated DNA positions in cancer, are thought to be oncogenic drivers because random chance is unlikely and the knowledge of clear examples of oncogenic hotspots in genes like BRAF, IDH1, KRAS and NRAS among many other genes. Hotspots are attractive because provide opportunities for biomedical research and novel treatments.

Nevertheless, recent evidence, such as DNA hairpins for APOBEC3A, suggests that a considerable fraction of hotspots seem to be passengers rather than drivers. To document hotspots, the database HotSpotsAnnotations is proposed. For this, a statistical model was implemented to detect putative hotspots, which was applied to TCGA cancer datasets covering 33 cancer types, 10 182 patients and 3 175 929 mutations.

Then, genes and hotspots were annotated by two published methods (APOBEC3A hairpins and dN/dS ratio) that may inform and warn researchers about possible false functional hotspots. Moreover, manual annotation from users can be added and shared. From the 23 198 detected as possible hotspots, 4435 were selected after false discovery rate correction and minimum mutation count. From these, 305 were annotated as likely for APOBEC3A whereas 442 were annotated as unlikely. To date, this is the first database dedicated to annotating hotspots for possible false functional hotspots.

CI-1040
T2443-1g 1g Ask for price
Description: CI-1040

CI-1040
T2443-1mg 1mg Ask for price
Description: CI-1040

CI-1040
T2443-50mg 50mg Ask for price
Description: CI-1040

CI-1040
T2443-5mg 5mg Ask for price
Description: CI-1040

KT 1
584533 50.0mg
EUR 315

KT 5720
532045 1.0mg
EUR 1650

KT 182
464890 5.0mg
EUR 265

KT 5823
B6673-.025 25ug
EUR 44
Description: MAPK Signaling|Protein Kinase G

KT 5823
B6673-.05 50 µg
EUR 76
Description: MAPK Signaling|Protein Kinase G

KT 5823
B6673-.1 100 µg
EUR 120
Description: MAPK Signaling|Protein Kinase G

KT 5823
B6673-.25 250 µg
EUR 249
Description: protein kinase G inhibitor

KT 5823
B6673-.5 500ug
EUR 468
Description: MAPK Signaling|Protein Kinase G

KT 5720
B9002-.05 50 µg
EUR 101.6
Description: MAPK Signaling|PKA

KT 5720
B9002-.1 100 µg
EUR 193.6
Description: MAPK Signaling|PKA

KT 5720
B9002-.25 250 µg
EUR 459.2
Description: MAPK Signaling|PKA

KT 5720
B9002-.5 500 µg
EUR 815.2
Description: MAPK Signaling|PKA

KT-5720
abx076628-250l 250 µl
EUR 212.5

KT-5720
abx076628-500l 500 µl
EUR 487.5

KT 5823
20-abx076629
  • Ask for price
  • Ask for price
  • 100 ug
  • 500 ug

KT-5823
abx076629-250l 250 µl
EUR 168.75

KT-5823
abx076629-500l 500 µl
EUR 462.5

KT-531
HY-128436 5mg
EUR 498.93
Description: KT-531 is a potent and selective inhibitor of HDAC6 with an IC50 of 8.5 nM. KT-531 exhibits strong inhibition against SUP-T11 cells with an IC50 of 0.42 μM. KT-531 can be used in study hematological cancers[1].

KT 5720
K660353 2.5mg
EUR 5100
Description: 108068-98-0

KT-474
HY-145483 1 mg
EUR 9415.73
Description: KT-474 (KYM-001) is an orally active PROTAC IRAK4 degrader with antitumor activities[1]. KT-474 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

KT 5720
MBS3841323-01mg 0.1mg
EUR 240

KT 5720
MBS3841323-5x01mg 5x0.1mg
EUR 1065

KT 5823
MBS3841328-01mg 0.1mg
EUR 270

KT 5823
MBS3841328-5x01mg 5x0.1mg
EUR 1205

KT-5823
MBS515006-25mg 25mg
EUR 240

KT-5823
MBS515006-5mg 5mg
EUR 195

KT-5823
MBS515006-5x25mg 5x25mg
EUR 820

KT 1
MBS5781993-50mg 50(mg
EUR 325

KT 1
MBS5781993-5mg 5mg
EUR 915

KT 1
MBS5781993-5x50mg 5x50mg
EUR 1320

KT 1
MBS5781993-5x5mg 5x5mg
EUR 3970

KT 5823
MBS808158-01mg 0.1mg
EUR 260

KT 5823
MBS808158-05mg 0.5mg
EUR 610

KT 5823
MBS808158-5x01mg 5x0.1mg
EUR 915

KT 5823
MBS808158-5x05mg 5x0.5mg
EUR 2480

KT 1
T32426-10mg 10mg Ask for price
Description: KT 1

KT 1
T32426-1g 1g Ask for price
Description: KT 1

KT 1
T32426-1mg 1mg Ask for price
Description: KT 1

KT 1
T32426-50mg 50mg Ask for price
Description: KT 1

KT 1
T32426-5mg 5mg Ask for price
Description: KT 1

PST- KT
PVT11358 2 ug
EUR 444

KT 5823
SIH-458-100UG 100 µg
EUR 112.8

KT 5823
SIH-458-500UG 500 µg
EUR 404

KT 5720
TRC-K660353-2.5MG 2.5 mg Ask for price

PD184352 (CI-1040)
A1792-100 100 mg
EUR 376
Description: MAPK Signaling|MEK1/2

PD184352 (CI-1040)
A1792-25 25 mg
EUR 144
Description: MAPK Signaling|MEK1/2

PD184352 (CI-1040)
A1792-5 5 mg
EUR 40
Description: MAPK Signaling|MEK1/2

PD184352 (CI-1040)
A1792-5.1 10 mM (in 1mL DMSO)
EUR 44
Description: MAPK Signaling|MEK1/2

DS-1040 (Tosylate)
HY-101918 10mM/1mL
EUR 1049.8
Description: DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases[1].

CI-1040 (PD184352)
E1KS1020 5mg
EUR 211.2

PD184352 (CI-1040)
MBS384508-100mg 100mg
EUR 545

PD184352 (CI-1040)
MBS384508-10mg 10mg
EUR 165

PD184352 (CI-1040)
MBS384508-1mLinDMSO 1mL(inDMSO)
EUR 185

PD184352 (CI-1040)
MBS384508-25mg 25mg
EUR 240

PD184352 (CI-1040)
MBS384508-5mg 5mg
EUR 130

DS-1040 Tosylate
MBS3844053-10mg 10mg
EUR 750

DS-1040 Tosylate
MBS3844053-1mg 1mg
EUR 205

DS-1040 Tosylate
MBS3844053-50mg 50mg
EUR 2130

DS-1040 Tosylate
MBS3844053-5mg 5mg
EUR 465

DS-1040 Tosylate
MBS3844053-5x50mg 5x50mg
EUR 9580

PD184352 (CI-1040)
MBS575639-100mg 100mg
EUR 410

PD184352 (CI-1040)
MBS575639-10mg 10mg
EUR 160

PD184352 (CI-1040)
MBS575639-25mg 25mg
EUR 220

PD184352 (CI-1040)
MBS575639-50mg 50mg
EUR 280

PD184352 (CI-1040)
MBS575639-5mg 5mg
EUR 140

DS-1040 Tosylate
MBS5753046-100mg 100mg
EUR 1905

DS-1040 Tosylate
MBS5753046-50mg 50mg
EUR 1145

DS-1040 Tosylate
MBS5753046-5x100mg 5x100mg
EUR 8430

CI-1040 (PD184352)
MBS8506222-5mg 5mg
EUR 290

CI-1040 (PD184352)
MBS8506222-5x5mg 5x5mg
EUR 1150

DS-1040 Tosylate
T11100-10mg 10mg Ask for price
Description: DS-1040 Tosylate

DS-1040 Tosylate
T11100-1g 1g Ask for price
Description: DS-1040 Tosylate

DS-1040 Tosylate
T11100-1mg 1mg Ask for price
Description: DS-1040 Tosylate

DS-1040 Tosylate
T11100-50mg 50mg Ask for price
Description: DS-1040 Tosylate

DS-1040 Tosylate
T11100-5mg 5mg Ask for price
Description: DS-1040 Tosylate

IN-KT 319
I627990 100mg
EUR 9200
Description: 1374790-37-0

KT-362 fumarate
MBS5777458-5mg 5(mg
EUR 915

KT-362 fumarate
MBS5777458-5x5mg 5x5(mg
EUR 3970

KT-362 fumarate
T27753-10mg 10mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-1g 1g Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-1mg 1mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-50mg 50mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-5mg 5mg Ask for price
Description: KT-362 fumarate

IN-KT 319
TRC-I627990-100MG 100 mg Ask for price

BDC2.5 mimotope 1040-31
MBS5789262-INQUIRE INQUIRE Ask for price

BDC2.5 mimotope 1040-51
MBS5789387-INQUIRE INQUIRE Ask for price

BDC2.5 mimotope 1040-31
TP1541-10mg 10mg Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-31
TP1541-1g 1g Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-31
TP1541-1mg 1mg Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-31
TP1541-50mg 50mg Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-31
TP1541-5mg 5mg Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-51
TP1679-10mg 10mg Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-51
TP1679-1g 1g Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-51
TP1679-1mg 1mg Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-51
TP1679-50mg 50mg Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-51
TP1679-5mg 5mg Ask for price
Description: BDC2.5 mimotope 1040-51

Forchlorfenuron (KT-30, CPPU)
C7187-1000 1g
EUR 68
Description: Others

Forchlorfenuron (KT-30, CPPU)
C7187-500 500mg
EUR 40
Description: Others

Forchlorfenuron (KT-30 CPPU)
MBS3610270-100mg 100mg
EUR 215

Forchlorfenuron (KT-30 CPPU)
MBS3610270-500mg 500mg
EUR 240

Forchlorfenuron (KT-30 CPPU)
MBS3610270-50mg 50mg
EUR 200

Forchlorfenuron (KT-30 CPPU)
MBS3610270-5x500mg 5x500mg
EUR 750

Forchlorfenuron (KT-30, CPPU)
MBS5751941-500mg 500mg
EUR 145

Forchlorfenuron (KT-30, CPPU)
MBS5751941-5x500mg 5x500mg
EUR 500

Polyclonal PER2 Antibody (aa1029-1040)
APR09040G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PER2 (aa1029-1040). This antibody is tested and proven to work in the following applications:

pLL3.7-CXCR4 shRNA (1040-1058)
PPL00187-4c 53bp
EUR 218
Description: pLL3.7

BDC2.5 mimotope 1040-31 acetate
TP1541L-10mg 10mg Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

BDC2.5 mimotope 1040-31 acetate
TP1541L-1g 1g Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

BDC2.5 mimotope 1040-31 acetate
TP1541L-1mg 1mg Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

BDC2.5 mimotope 1040-31 acetate
TP1541L-50mg 50mg Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

BDC2.5 mimotope 1040-31 acetate
TP1541L-5mg 5mg Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

2019-nCov Spike Protein (1040-1091)
071-60 100 μg
EUR 502.2

STN-1040- 210X297-B7527 AC Signs
803991 Card of 1 Pictogram(s)
EUR 10.2
Description: Description Dutch: Pictogram voor Machineveiligheid - Let op uw handen - LET OP UW HANDEN; Description French: Pictogramme - Avertissement - LET OP UW HANDEN

pLL3.7-CXCR4 shRNA (1040-1058) Plasmid
PVTB00187-4c 2 ug
EUR 427.2

Plasminogen Receptor (KT) (PLGRKT) Antibody
abx318476-100l 100 µl
EUR 250

Plasminogen Receptor (KT) (PLGRKT) Antibody
20-abx318476
  • Ask for price
  • Ask for price
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  • Ask for price
  • Ask for price
  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

Plasminogen Receptor (KT) (PLGRKT) Antibody
abx318476-50l 50 µl
EUR 162.5

Recombinant Rat Plasminogen receptor (KT)
MBS1142402-INQUIRE INQUIRE Ask for price

11-KT(11-ketoTestosterone)ELISAKit
ELK8908-48T 48T
EUR 160
Description: Competitive Inhibition

11-KT(11-ketoTestosterone)ELISAKit
ELK8908-96T 96T
EUR 229
Description: Competitive Inhibition

Recombinant Rat Plasminogen receptor (KT)
MBS7039515-002mg 0.02mg
EUR 1420

Recombinant Rat Plasminogen receptor (KT)
MBS7039515-01mg 0.1mg
EUR 2385

Recombinant Rat Plasminogen receptor (KT)
MBS7039515-5x01mg 5x0.1mg
EUR 10690

Recombinant Mouse Plasminogen receptor (KT)
MBS7038675-002mg 0.02mg
EUR 1420

Recombinant Mouse Plasminogen receptor (KT)
MBS7038675-01mg 0.1mg
EUR 2385

Recombinant Mouse Plasminogen receptor (KT)
MBS7038675-5x01mg 5x0.1mg
EUR 10690

Liquiport NF 100 KT. - EACH
PUM2680 EACH
EUR 1035.45

Cochranes molecular models 1 KT
Z184756-1KT 1KIT
EUR 26.9

6-KT Storage Solution (Sterile)
K8331
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 5 mL
  • 10 mL
  • 5x 1 mL
  • 100 mL

KT-30 Storage Solution (Sterile)
K8340 100 mL Ask for price

STN-1040-148*210-B7541 AC Signs
803990 Card of 1 Pictogram(s)
EUR 6.5
Description: Description Dutch: Pictogram voor Machineveiligheid - Let op uw handen - LET OP UW HANDEN; Description French: Pictogramme - Avertissement - LET OP UW HANDEN

STF-1040-148*210-B7541 AC Signs
803992 Card of 1 Pictogram(s)
EUR 6.5
Description: Description Dutch: Waarschuwingspictogram - ATTENTION A VOS MAINS; Description French: Panneau de Danger - Attention à vos mains

STF-1040-210*297-B7527 AC Signs
803993 Card of 1 Pictogram(s)
EUR 15.95
Description: Description Dutch: Waarschuwingspictogram - ATTENTION A VOS MAINS; Description French: Panneau de Danger - Attention à vos mains

Recombinant Rat Plasminogen receptor (KT), partial
MBS7069426-INQUIRE INQUIRE Ask for price

Recombinant Human Plasminogen receptor (KT) (C9orf46)
MBS7010620-002mg 0.02mg
EUR 1420

Recombinant Human Plasminogen receptor (KT) (C9orf46)
MBS7010620-01mg 0.1mg
EUR 2385