HotSpotAnnotations-a database for hotspot mutations and annotations in cancer.

Hotspots, recurrently mutated DNA positions in cancer, are thought to be oncogenic drivers because random chance is unlikely and the knowledge of clear examples of oncogenic hotspots in genes like BRAF, IDH1, KRAS and NRAS among many other genes. Hotspots are attractive because provide opportunities for biomedical research and novel treatments.

Nevertheless, recent evidence, such as DNA hairpins for APOBEC3A, suggests that a considerable fraction of hotspots seem to be passengers rather than drivers. To document hotspots, the database HotSpotsAnnotations is proposed. For this, a statistical model was implemented to detect putative hotspots, which was applied to TCGA cancer datasets covering 33 cancer types, 10 182 patients and 3 175 929 mutations.

Then, genes and hotspots were annotated by two published methods (APOBEC3A hairpins and dN/dS ratio) that may inform and warn researchers about possible false functional hotspots. Moreover, manual annotation from users can be added and shared. From the 23 198 detected as possible hotspots, 4435 were selected after false discovery rate correction and minimum mutation count. From these, 305 were annotated as likely for APOBEC3A whereas 442 were annotated as unlikely. To date, this is the first database dedicated to annotating hotspots for possible false functional hotspots.

KT 5720
B9002-.1	ApexBio	100 µg	EUR 232

KT 5720
B9002-.25	ApexBio	250 µg	EUR 483

KT 5720
B9002-.5	ApexBio	500 µg	EUR 818

KT 5823
B6673-.05	ApexBio	50 µg	EUR 123

KT 5823
B6673-.1	ApexBio	100 µg	EUR 190

KT 5823
B6673-.25	ApexBio	250 µg	EUR 361

DS-1040 (Tosylate)
HY-101918	MedChemExpress	10mM/1mL	EUR 403

CI-1040 (PD184352)
E1KS1020	EnoGene	5mg	EUR 325

PD184352 (CI-1040)
A1792-100	ApexBio	100 mg	EUR 595
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1]

PD184352 (CI-1040)
A1792-25	ApexBio	25 mg	EUR 258
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1]

PD184352 (CI-1040)
A1792-5	ApexBio	5 mg	EUR 108
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1]

PD184352 (CI-1040)
A1792-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: PD184352 (also known as CI-1040), a benzhydroxamate derivative, is a potent and highly selective MEK1/2, two members of the family of MAPKKs, inhibitor that inhibits purified MEK1 with IC50 of 17 nM in a non-ATP and non-ERK1/2 competitive manner [1]

Mouse C-Reactive Protein (CRP) ELISA Kit, 96 tests, Quantitative
1040	Alpha Diagnostics	1 kit	EUR 773

Polyclonal PER2 Antibody (aa1029-1040)
APR09040G	Leading Biology	0.05mg	EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PER2 (aa1029-1040). This antibody is tested and proven to work in the following applications:

Plasminogen Receptor (KT) (PLGRKT) Antibody
20-abx318476	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

KT 5823 (PKG kinase inhibitor)
SIH-458-100UG	Stressmarq	100 µg	EUR 205
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)
SIH-458-500UG	Stressmarq	500 µg	EUR 569
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

pLL3.7-CXCR4 shRNA (1040-1058) Plasmid
PVTB00187-4c	Lifescience Market	2 ug	EUR 356

Recombinant Candida Albicans SET1 Protein (aa 1-1040)
VAng-Lsx05943-inquire	Creative Biolabs	inquire	Ask for price
Description: Candida Albicans (strain SC5314 / ATCC MYA-2876) Histone-lysine N-methyltransferase, H3 lysine-4 specific, recombinant protein.

Recombinant Shigella Sonnei mdtB Protein (aa 1-1040)
VAng-Lsx09858-inquire	Creative Biolabs	inquire	Ask for price
Description: Shigella Sonnei (strain Ss046) Multidrug resistance protein MdtB, recombinant protein.

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-48T	GenAsia Biotech	48T	EUR 317

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-96T	GenAsia Biotech	96T	EUR 496

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E11201	Qayee Biotechnology	96T	EUR 361

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E20317	Qayee Biotechnology	96T	EUR 361

MBP antibody (Prediluted for IHC)
75R-1040	Fitzgerald	7 ml	EUR 187
Description: Rabbit polyclonal MBP antibody (Prediluted for IHC)

Buprenorphine-BSA
80-1040	Fitzgerald	1 mg	EUR 136
Description: Conjugated Buprenorphine-BSA hapten

IPP1 protein (His tag)
80R-1040	Fitzgerald	100 ug	EUR 305
Description: Purified recombinant Human IPP1 protein

Alpha 2 Macroglobulin protein
30-1040	Fitzgerald	1 mg	EUR 284
Description: Purified native Human Alpha 2 Macroglobulin protein

PEX3 antibody
70R-1040	Fitzgerald	100 ug	EUR 377
Description: Rabbit polyclonal PEX3 antibody raised against the N terminal of PEX3

DDX47 Blocking Peptide
33R-1040	Fitzgerald	100 ug	EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of WIPF2 antibody, catalog no. 70R-4505

Mouse Ig fraction
31R-1040	Fitzgerald	10 mg	EUR 150
Description: Purified Mouse Ig fraction for use as a control or blocking reagent

Goat anti Human IgG + IgA + IgM
41R-1040	Fitzgerald	1 mg	EUR 144
Description: Goat anti Human IgG + IgA + IgM secondary antibody

Canine Factor VIII Antibody Pair
55R-1040	Fitzgerald	4 plates	EUR 899
Description: Canine Factor VIII antigen Matched Pair antibody Set for ELISA

Chicken anti Goat IgG (H + L) (biotin)
43R-1040	Fitzgerald	500 ug	EUR 207
Description: Chicken anti Goat IgG (H + L) secondary antibody (biotin)

Anti-p38 beta
DB-1040	DB Biotech	100 tests	EUR 474

Piggy? Tube Rotator, including rotisserie for 42 x 0.5mL~0.8mL tubes, 2/pk, 50 x 1.5mL~2.0mL tubes, 2/pk, rotisserie for 14 x 5mL~7mL tubes, 2/pk, rotisserie for 14 x 10mL~15mL tubes, 2/pk, rotisserie for 6 x 50mL tubs, 1/pk
ACT-1040	ACTGene		EUR 707

Mouse C-Reactive Protein (CRP) reference serum (~1 ug/ml)
1040-RS	Alpha Diagnostics	1 ml	EUR 202

MethylFlash Urine 5-Methylcytosine (5-mC) Quantification Kit (Fluorometric)
P-1040	EpiGentek	96 Assays	EUR 788.05
Description: The best epigenetics products

Histone H3K79me1 Monomethyl Peptide
R-1040	EpiGentek	200 µl	EUR 442.95
Description: kits suitable for this type of research

Angiotensin II Acetate (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe; 1046.18)
PP-1040	Alpha Diagnostics	Bulk	Ask for price

Recombinant Mouse (E.Coli) GRO-beta/MIP-2 (CXCL2)
RP-1040	Alpha Diagnostics	5 ug	EUR 164

Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain Sb227)
VAng-Lsx09209-inquire	Creative Biolabs	inquire	Ask for price
Description: Shigella Boydii serotype 4 (strain Sb227) Multidrug resistance protein MdtB, recombinant protein.

Recombinant Klebsiella Pneumoniae mdtB Protein (aa 1-1040) (strain 342)
VAng-Cr5077-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 3830
Description: Klebsiella Pneumoniae (strain 342) Multidrug resistance protein MdtB (mdtB), recombinant protein.

Factor XI Antibody Pair
55R-FAC11-KT	Fitzgerald	5 plates	EUR 745
Description: Factor XI antigen Matched Pair antibody Set for ELISA

Factor IX Antibody Pair
55R-FAC9-KT	Fitzgerald	5 plates	EUR 760
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set
55R-FIBRINO-KT	Fitzgerald	set	EUR 833
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

Mouse RANKL ELISA Kit
55R-MRANKL-KT	Fitzgerald	1 kit	EUR 658
Description: ELISA kit for detection of Mouse RANKL in the research laboratory

VWF Antibody Pair
55R-VWF-KT	Fitzgerald	5 plates	EUR 775
Description: VWF antigen Matched Pair antibody Set for ELISA

Human 8-iso prostaglandin,8-iso-PG ELISA Kit
201-12-1040	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Magnetic platform, includes 4 metal mounting strips, accessory for Piggy? Tube Rotator
ACT-1040-6	ACTGene		EUR 297

Anti-EGFR (Panitumumab)-SMCC-DM1 ADC
ADC-W-1040	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody conjugated via a SMCC linker to DM1

Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain CDC 3083-94 / BS512)
VAng-Lsx08698-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 3830
Description: Shigella Boydii serotype 18 (strain CDC 3083-94 / BS512) Multidrug resistance protein MdtB, recombinant protein.

Recombinant Shigella Boydii mdtB Protein (aa 1-1040) (strain CDC 3083-94 / BS512)
VAng-Lsx08698-1mgYeast	Creative Biolabs	1 mg (Yeast)	EUR 5095
Description: Shigella Boydii serotype 18 (strain CDC 3083-94 / BS512) Multidrug resistance protein MdtB, recombinant protein.

Recombinant Klebsiella Pneumoniae mdtB Protein (aa 1-1040) (strain ATCC 700721 / MGH 78578)
VAng-Cr5078-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 3830
Description: Klebsiella Pneumoniae (strain ATCC 700721 / MGH 78578) Multidrug resistance protein MdtB (mdtB), recombinant protein.