HotSpotAnnotations-a database for hotspot mutations and annotations in cancer.

Hotspots, recurrently mutated DNA positions in cancer, are thought to be oncogenic drivers because random chance is unlikely and the knowledge of clear examples of oncogenic hotspots in genes like BRAF, IDH1, KRAS and NRAS among many other genes. Hotspots are attractive because provide opportunities for biomedical research and novel treatments.

Nevertheless, recent evidence, such as DNA hairpins for APOBEC3A, suggests that a considerable fraction of hotspots seem to be passengers rather than drivers. To document hotspots, the database HotSpotsAnnotations is proposed. For this, a statistical model was implemented to detect putative hotspots, which was applied to TCGA cancer datasets covering 33 cancer types, 10 182 patients and 3 175 929 mutations.

Then, genes and hotspots were annotated by two published methods (APOBEC3A hairpins and dN/dS ratio) that may inform and warn researchers about possible false functional hotspots. Moreover, manual annotation from users can be added and shared. From the 23 198 detected as possible hotspots, 4435 were selected after false discovery rate correction and minimum mutation count. From these, 305 were annotated as likely for APOBEC3A whereas 442 were annotated as unlikely. To date, this is the first database dedicated to annotating hotspots for possible false functional hotspots.

CI-1040
T2443-1mg	TargetMol Chemicals	1mg	Ask for price
Description: CI-1040

CI-1040
T2443-50mg	TargetMol Chemicals	50mg	Ask for price
Description: CI-1040

CI-1040
T2443-5mg	TargetMol Chemicals	5mg	Ask for price
Description: CI-1040

SNU-1040
CSC-C9616L	Creative Bioarray	One Frozen vial	Ask for price
Description: Colorectal Carcinoma Cells

KT 5823
20-abx076629	Abbexa	Ask for price Ask for price	100 ug 500 ug

KT 1
584533	MedKoo Biosciences	50.0mg	EUR 315

KT 5720
532045	MedKoo Biosciences	1.0mg	EUR 1650

KT 182
464890	MedKoo Biosciences	5.0mg	EUR 265

KT 5720
B9002-.05	ApexBio	50 µg	EUR 77
Description: protein kinase A inhibitor, potent and selective

KT 5720
B9002-.1	ApexBio	100 µg	EUR 146
Description: protein kinase A inhibitor, potent and selective

KT 5720
B9002-.25	ApexBio	250 µg	EUR 345
Description: protein kinase A inhibitor, potent and selective

KT 5720
B9002-.5	ApexBio	500 µg	EUR 611
Description: protein kinase A inhibitor, potent and selective

KT 5823
B6673-.05	ApexBio	50 µg	EUR 59
Description: protein kinase G inhibitor

KT 5823
B6673-.1	ApexBio	100 µg	EUR 112
Description: protein kinase G inhibitor

KT 5823
B6673-.25	ApexBio	250 µg	EUR 249
Description: protein kinase G inhibitor

KT 5720
K660353	Toronto Research Chemicals	2.5mg	EUR 5100
Description: 108068-98-0

KT 5823
SIH-458-100UG	Stressmarq	100 µg	EUR 141
Description: PKG kinase inhibitor

KT 5823
SIH-458-500UG	Stressmarq	500 µg	EUR 505
Description: PKG kinase inhibitor

KT 1
T32426-10mg	TargetMol Chemicals	10mg	Ask for price
Description: KT 1

KT 1
T32426-1g	TargetMol Chemicals	1g	Ask for price
Description: KT 1

KT 1
T32426-1mg	TargetMol Chemicals	1mg	Ask for price
Description: KT 1

KT 1
T32426-50mg	TargetMol Chemicals	50mg	Ask for price
Description: KT 1

KT 1
T32426-5mg	TargetMol Chemicals	5mg	Ask for price
Description: KT 1

KT-5720
abx076628-250l	Abbexa	250 µl	EUR 212.5

KT-5720
abx076628-500l	Abbexa	500 µl	EUR 487.5

KT-5823
abx076629-250l	Abbexa	250 µl	EUR 168.75

KT-5823
abx076629-500l	Abbexa	500 µl	EUR 462.5

KT 5823
B6673-.025	ApexBio	25ug	EUR 44
Description: MAPK Signaling|Protein Kinase G

KT 5823
B6673-.5	ApexBio	500ug	EUR 468
Description: MAPK Signaling|Protein Kinase G

KT 1
MBS5781993-50mg	MyBiosource	50(mg	EUR 325

KT 1
MBS5781993-5mg	MyBiosource	5mg	EUR 915

KT 1
MBS5781993-5x50mg	MyBiosource	5x50mg	EUR 1320

KT 1
MBS5781993-5x5mg	MyBiosource	5x5mg	EUR 3970

KT 5823
MBS808158-01mg	MyBiosource	0.1mg	EUR 260

KT 5823
MBS808158-05mg	MyBiosource	0.5mg	EUR 610

KT 5823
MBS808158-5x01mg	MyBiosource	5x0.1mg	EUR 915

KT 5823
MBS808158-5x05mg	MyBiosource	5x0.5mg	EUR 2480

KT 5720
MBS3841323-01mg	MyBiosource	0.1mg	EUR 240

KT 5720
MBS3841323-5x01mg	MyBiosource	5x0.1mg	EUR 1065

KT 5823
MBS3841328-01mg	MyBiosource	0.1mg	EUR 270

KT 5823
MBS3841328-5x01mg	MyBiosource	5x0.1mg	EUR 1205

KT-5823
MBS515006-25mg	MyBiosource	25mg	EUR 240

KT-5823
MBS515006-5mg	MyBiosource	5mg	EUR 195

KT-5823
MBS515006-5x25mg	MyBiosource	5x25mg	EUR 820

PST- KT
PVT11358	Nova Lifetech	2ug	EUR 260

CI-1040 (PD184352)
E1KS1020	EnoGene	5mg	EUR 211.2

PD184352 (CI-1040)
A1792-100	ApexBio	100 mg	EUR 376
Description: Selective MEK inhibitor

PD184352 (CI-1040)
A1792-25	ApexBio	25 mg	EUR 144
Description: Selective MEK inhibitor

PD184352 (CI-1040)
A1792-5	ApexBio	5 mg	EUR 40
Description: Selective MEK inhibitor

PD184352 (CI-1040)
A1792-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 44
Description: Selective MEK inhibitor

DS-1040 (Tosylate)
HY-101918	MedChemExpress	10mM/1mL	EUR 483.6

DS-1040 Tosylate
T11100-10mg	TargetMol Chemicals	10mg	Ask for price
Description: DS-1040 Tosylate

DS-1040 Tosylate
T11100-1g	TargetMol Chemicals	1g	Ask for price
Description: DS-1040 Tosylate

DS-1040 Tosylate
T11100-1mg	TargetMol Chemicals	1mg	Ask for price
Description: DS-1040 Tosylate

DS-1040 Tosylate
T11100-50mg	TargetMol Chemicals	50mg	Ask for price
Description: DS-1040 Tosylate

DS-1040 Tosylate
T11100-5mg	TargetMol Chemicals	5mg	Ask for price
Description: DS-1040 Tosylate

CI-1040 (PD184352)
MBS8506222-5mg	MyBiosource	5mg	EUR 290

CI-1040 (PD184352)
MBS8506222-5x5mg	MyBiosource	5x5mg	EUR 1150

PD184352 (CI-1040)
MBS384508-100mg	MyBiosource	100mg	EUR 545

PD184352 (CI-1040)
MBS384508-10mg	MyBiosource	10mg	EUR 165

PD184352 (CI-1040)
MBS384508-1mLinDMSO	MyBiosource	1mL(inDMSO)	EUR 185

PD184352 (CI-1040)
MBS384508-25mg	MyBiosource	25mg	EUR 240

PD184352 (CI-1040)
MBS384508-5mg	MyBiosource	5mg	EUR 130

DS-1040 Tosylate
MBS3844053-10mg	MyBiosource	10mg	EUR 750

DS-1040 Tosylate
MBS3844053-1mg	MyBiosource	1mg	EUR 205

DS-1040 Tosylate
MBS3844053-50mg	MyBiosource	50mg	EUR 2130

DS-1040 Tosylate
MBS3844053-5mg	MyBiosource	5mg	EUR 465

DS-1040 Tosylate
MBS3844053-5x50mg	MyBiosource	5x50mg	EUR 9580

DS-1040 Tosylate
MBS5753046-100mg	MyBiosource	100mg	EUR 1905

DS-1040 Tosylate
MBS5753046-50mg	MyBiosource	50mg	EUR 1145

DS-1040 Tosylate
MBS5753046-5x100mg	MyBiosource	5x100mg	EUR 8430

PD184352 (CI-1040)
MBS575639-100mg	MyBiosource	100mg	EUR 410

PD184352 (CI-1040)
MBS575639-10mg	MyBiosource	10mg	EUR 160

PD184352 (CI-1040)
MBS575639-25mg	MyBiosource	25mg	EUR 220

PD184352 (CI-1040)
MBS575639-50mg	MyBiosource	50mg	EUR 280

PD184352 (CI-1040)
MBS575639-5mg	MyBiosource	5mg	EUR 140

BDC2.5 mimotope 1040-31
TP1541-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-31
TP1541-1g	TargetMol Chemicals	1g	Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-31
TP1541-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-31
TP1541-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-31
TP1541-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BDC2.5 mimotope 1040-31

BDC2.5 mimotope 1040-51
TP1679-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-51
TP1679-1g	TargetMol Chemicals	1g	Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-51
TP1679-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-51
TP1679-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-51
TP1679-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BDC2.5 mimotope 1040-51

BDC2.5 mimotope 1040-31
MBS5789262-INQUIRE	MyBiosource	INQUIRE	Ask for price

BDC2.5 mimotope 1040-51
MBS5789387-INQUIRE	MyBiosource	INQUIRE	Ask for price

IN-KT 319
I627990	Toronto Research Chemicals	100mg	EUR 9200
Description: 1374790-37-0

KT-362 fumarate
T27753-10mg	TargetMol Chemicals	10mg	Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-1g	TargetMol Chemicals	1g	Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-1mg	TargetMol Chemicals	1mg	Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-50mg	TargetMol Chemicals	50mg	Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-5mg	TargetMol Chemicals	5mg	Ask for price
Description: KT-362 fumarate

KT-362 fumarate
MBS5777458-5mg	MyBiosource	5(mg	EUR 915

KT-362 fumarate
MBS5777458-5x5mg	MyBiosource	5x5(mg	EUR 3970

Polyclonal PER2 Antibody (aa1029-1040)
APR09040G	Leading Biology	0.05mg	EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PER2 (aa1029-1040). This antibody is tested and proven to work in the following applications:

BDC2.5 mimotope 1040-31 acetate
TP1541L-10mg	TargetMol Chemicals	10mg	Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

BDC2.5 mimotope 1040-31 acetate
TP1541L-1g	TargetMol Chemicals	1g	Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

BDC2.5 mimotope 1040-31 acetate
TP1541L-1mg	TargetMol Chemicals	1mg	Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

BDC2.5 mimotope 1040-31 acetate
TP1541L-50mg	TargetMol Chemicals	50mg	Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

BDC2.5 mimotope 1040-31 acetate
TP1541L-5mg	TargetMol Chemicals	5mg	Ask for price
Description: BDC2.5 mimotope 1040-31 acetate

Forchlorfenuron (KT-30, CPPU)
C7187-1000	ApexBio	1g	EUR 68

Forchlorfenuron (KT-30, CPPU)
C7187-500	ApexBio	500mg	EUR 40

Ketoconazole KT 10 mcg
SD224-1PK	EWC Diagnostics	1 unit	EUR 6.31
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 10 mcg
SD224-1VL	EWC Diagnostics	1 unit	EUR 2.99
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 10 mcg
SD224-5CT	EWC Diagnostics	1 unit	EUR 6.65
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 10 mcg
SD224-5VL	EWC Diagnostics	1 unit	EUR 11.84
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 10 mcg
SD224-5X50DS	EWC Diagnostics	1 unit	EUR 6.5
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 50 mcg
SD274-1PK	EWC Diagnostics	1 unit	EUR 6.31
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 50 mcg
SD274-1VL	EWC Diagnostics	1 unit	EUR 2.99
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 50 mcg
SD274-5CT	EWC Diagnostics	1 unit	EUR 6.65
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 50 mcg
SD274-5VL	EWC Diagnostics	1 unit	EUR 11.84
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 50 mcg
SD274-5X50DS	EWC Diagnostics	1 unit	EUR 6.5
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 30 mcg
SD275-1PK	EWC Diagnostics	1 unit	EUR 6.31
Description: Ketoconazole KT 30 mcg

Ketoconazole KT 30 mcg
SD275-1VL	EWC Diagnostics	1 unit	EUR 2.99
Description: Ketoconazole KT 30 mcg

Ketoconazole KT 30 mcg
SD275-5CT	EWC Diagnostics	1 unit	EUR 6.65
Description: Ketoconazole KT 30 mcg

Ketoconazole KT 30 mcg
SD275-5VL	EWC Diagnostics	1 unit	EUR 11.84
Description: Ketoconazole KT 30 mcg

Ketoconazole KT 30 mcg
SD275-5X50DS	EWC Diagnostics	1 unit	EUR 6.5
Description: Ketoconazole KT 30 mcg

Forchlorfenuron (KT-30 CPPU)
MBS3610270-100mg	MyBiosource	100mg	EUR 215

Forchlorfenuron (KT-30 CPPU)
MBS3610270-500mg	MyBiosource	500mg	EUR 240

Forchlorfenuron (KT-30 CPPU)
MBS3610270-50mg	MyBiosource	50mg	EUR 200

Forchlorfenuron (KT-30 CPPU)
MBS3610270-5x500mg	MyBiosource	5x500mg	EUR 750

Forchlorfenuron (KT-30, CPPU)
MBS5751941-500mg	MyBiosource	500mg	EUR 145

Forchlorfenuron (KT-30, CPPU)
MBS5751941-5x500mg	MyBiosource	5x500mg	EUR 500

2019-nCov Spike Protein (1040-1091)
071-60	PHOENIX PEPTIDE	100 μg	EUR 502.2

STN-1040- 210X297-B7527 AC Signs
803991	BRADY NV	Card of 1 Pictogram(s)	EUR 10.2
Description: Description Dutch: Pictogram voor Machineveiligheid - Let op uw handen - LET OP UW HANDEN; Description French: Pictogramme - Avertissement - LET OP UW HANDEN

pLL3.7-CXCR4 shRNA (1040-1058) Plasmid
PVTB00187-4c	Nova Lifetech	2ug	EUR 288

Plasminogen Receptor (KT) (PLGRKT) Antibody
20-abx318476	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Cochranes molecular models 1 KT
Z184756-1KT	Scientific Laboratory Supplies	1KIT	EUR 26.9

Recombinant Rat Plasminogen receptor (KT)
MBS1142402-INQUIRE	MyBiosource	INQUIRE	Ask for price

Liquiport NF 100 KT. - EACH
PUM2680	Scientific Laboratory Supplies	EACH	EUR 1035.45

Plasminogen Receptor (KT) (PLGRKT) Antibody
abx318476-100l	Abbexa	100 µl	EUR 250

Plasminogen Receptor (KT) (PLGRKT) Antibody
abx318476-50l	Abbexa	50 µl	EUR 162.5

Recombinant Mouse Plasminogen receptor (KT)
MBS7038675-002mg	MyBiosource	0.02mg	EUR 1420

Recombinant Mouse Plasminogen receptor (KT)
MBS7038675-01mg	MyBiosource	0.1mg	EUR 2385

Recombinant Mouse Plasminogen receptor (KT)
MBS7038675-5x01mg	MyBiosource	5x0.1mg	EUR 10690

Recombinant Rat Plasminogen receptor (KT)
MBS7039515-002mg	MyBiosource	0.02mg	EUR 1420

Recombinant Rat Plasminogen receptor (KT)
MBS7039515-01mg	MyBiosource	0.1mg	EUR 2385

Recombinant Rat Plasminogen receptor (KT)
MBS7039515-5x01mg	MyBiosource	5x0.1mg	EUR 10690