Hot spot 19 F magnetic resonance imaging of inflammation.

Among the preclinical molecular imaging approaches, lately fluorine (19 F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community, due to the unique properties of fluorinated materials and the 19 F nucleus. Fluorine is an intrinsically sensitive nucleus for MRI-there is negligible endogenous 19 F in the body and, thus, no background signal which allows the detection of fluorinated materials as “hot spots” by combined 1 H/19 F MRI and renders fluorine-containing molecules as ideal tracers with high specificity.

In addition, perfluorocarbons are a family of compounds that exhibit a very high fluorine payload and are biochemically as well as physiologically inert. Perfluorocarbon nanoemulsions (PFCs) are well known to be readily taken up by immunocompetent cells, which can be exploited for the unequivocal identification of inflammatory foci by tracking the recruitment of PFC-loaded immune cells to affected tissues using 1 H/19 F MRI.

The required 19 F labeling of immune cells can be accomplished either ex vivo by PFC incubation of isolated endogenous immune cells followed by their re-injection or by intravenous application of PFCs for in situ uptake by circulating immune cells. With both approaches, inflamed tissues can unambiguously be detected via background-free 19 F signals due to trafficking of PFC-loaded immune cells to affected organs.

To extend 19 F MRI tracking beyond cells with phagocytic properties, the PFC surface can further be equipped with distinct ligands to generate specificity against epitopes and/or types of immune cells independent of phagocytosis. Recent developments also allow for concurrent detection of different PFCs with distinct spectral signatures allowing the simultaneous visualization of several targets, such as various immune cell subtypes labeled with these PFCs.

Since ligands and targets can easily be adapted to a variety of problems, this approach provides a general and versatile platform for inflammation imaging which will strongly extend the frontiers of molecular MRI. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease.

Nanomagnetic 50nm magnetic beads are available from Gentaur and Clemente associates.

KT 5720
B9002-.05 50 µg
EUR 77
Description: protein kinase A inhibitor, potent and selective

KT 5720
B9002-.1 100 µg
EUR 146
Description: protein kinase A inhibitor, potent and selective

KT 5720
B9002-.25 250 µg
EUR 345
Description: protein kinase A inhibitor, potent and selective

KT 5720
B9002-.5 500 µg
EUR 611
Description: protein kinase A inhibitor, potent and selective

KT 5823
B6673-.05 50 µg
EUR 59
Description: protein kinase G inhibitor

KT 5823
B6673-.1 100 µg
EUR 112
Description: protein kinase G inhibitor

KT 5823
B6673-.25 250 µg
EUR 249
Description: protein kinase G inhibitor

KT 5720
K660353 2.5mg
EUR 5100
Description: 108068-98-0

PST- KT
PVT11358 2 ug
EUR 444

KT 5823
SIH-458-100UG 100 µg
EUR 141
Description: PKG kinase inhibitor

KT 5823
SIH-458-500UG 500 µg
EUR 505
Description: PKG kinase inhibitor

KT 1
T32426-10mg 10mg Ask for price
Description: KT 1

KT 1
T32426-1g 1g Ask for price
Description: KT 1

KT 1
T32426-1mg 1mg Ask for price
Description: KT 1

KT 1
T32426-50mg 50mg Ask for price
Description: KT 1

KT 1
T32426-5mg 5mg Ask for price
Description: KT 1

KT-5720
abx076628-250l 250 µl
EUR 212.5

KT-5720
abx076628-500l 500 µl
EUR 487.5

KT-5823
abx076629-250l 250 µl
EUR 168.75

KT-5823
abx076629-500l 500 µl
EUR 462.5

BAR-502
530640 100.0mg
EUR 850

BAR-502
B1965-25 each
EUR 757.2

BAR-502
B1965-5 each
EUR 235.2

NCT-502
C5478-10 10 mg
EUR 146
Description: inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH)

NCT-502
C5478-25 25 mg
EUR 328
Description: inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH)

NCT-502
C5478-5 5 mg
EUR 81
Description: inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH)

NCT-502
561459 5.0mg
EUR 220

NCT-502
HY-117240 50mg
EUR 445.2

KS 502
T32422-10mg 10mg Ask for price
Description: KS 502

KS 502
T32422-1g 1g Ask for price
Description: KS 502

KS 502
T32422-1mg 1mg Ask for price
Description: KS 502

KS 502
T32422-50mg 50mg Ask for price
Description: KS 502

KS 502
T32422-5mg 5mg Ask for price
Description: KS 502

Btg 502
T23827-10mg 10mg Ask for price
Description: Btg 502

Btg 502
T23827-1g 1g Ask for price
Description: Btg 502

Btg 502
T23827-1mg 1mg Ask for price
Description: Btg 502

Btg 502
T23827-50mg 50mg Ask for price
Description: Btg 502

Btg 502
T23827-5mg 5mg Ask for price
Description: Btg 502

NCT-502
T16277-10mg 10mg Ask for price
Description: NCT-502

NCT-502
T16277-1g 1g Ask for price
Description: NCT-502

NCT-502
T16277-1mg 1mg Ask for price
Description: NCT-502

NCT-502
T16277-50mg 50mg Ask for price
Description: NCT-502

NCT-502
T16277-5mg 5mg Ask for price
Description: NCT-502

GNE-502
T39369-10mg 10mg Ask for price
Description: GNE-502

GNE-502
T39369-1g 1g Ask for price
Description: GNE-502

GNE-502
T39369-1mg 1mg Ask for price
Description: GNE-502

GNE-502
T39369-50mg 50mg Ask for price
Description: GNE-502

GNE-502
T39369-5mg 5mg Ask for price
Description: GNE-502

IN-KT 319
I627990 100mg
EUR 9200
Description: 1374790-37-0

KT-362 fumarate
T27753-10mg 10mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-1g 1g Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-1mg 1mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-50mg 50mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate
T27753-5mg 5mg Ask for price
Description: KT-362 fumarate

WML-502-502-4S AF Systems Consumables
032525 Roll of 1000 Label(s)
EUR 60.12
Description: Description Dutch: LS 2000 & BradyMarker XC Plus Printer Labels; Description French: Etiquettes LS 2000 & BradyMarker XC Plus

WML-502-502-2S AF Systems Consumables
032531 Roll of 500 Label(s)
EUR 46.96
Description: Description Dutch: LS 2000 & BradyMarker XC Plus Printer Labels; Description French: Etiquettes LS 2000 & BradyMarker XC Plus

Biolipidure-502-Reagent
Biolipidure-502-10 10mL
EUR 235.2
Description: The Biolipidure-502 Reagent is a synthetic cationic polymer. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Biolipidure-502-Reagent
Biolipidure-502-100 100mL
EUR 1467.6
Description: The Biolipidure-502 Reagent is a synthetic cationic polymer. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

BAR 502-d5
B161226 75mg
EUR 12800

Forchlorfenuron (KT-30, CPPU)
C7187-1000 1g
EUR 68

Forchlorfenuron (KT-30, CPPU)
C7187-500 500mg
EUR 40

Ketoconazole KT 10 mcg
SD224-1PK 1 unit
EUR 6.31
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 10 mcg
SD224-1VL 1 unit
EUR 2.99
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 10 mcg
SD224-5CT 1 unit
EUR 6.65
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 10 mcg
SD224-5VL 1 unit
EUR 11.84
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 10 mcg
SD224-5X50DS 1 unit
EUR 6.5
Description: Ketoconazole KT 10 mcg

Ketoconazole KT 50 mcg
SD274-1PK 1 unit
EUR 6.31
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 50 mcg
SD274-1VL 1 unit
EUR 2.99
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 50 mcg
SD274-5CT 1 unit
EUR 6.65
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 50 mcg
SD274-5VL 1 unit
EUR 11.84
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 50 mcg
SD274-5X50DS 1 unit
EUR 6.5
Description: Ketoconazole KT 50 mcg

Ketoconazole KT 30 mcg
SD275-1PK 1 unit
EUR 6.31
Description: Ketoconazole KT 30 mcg

Ketoconazole KT 30 mcg
SD275-1VL 1 unit
EUR 2.99
Description: Ketoconazole KT 30 mcg

Ketoconazole KT 30 mcg
SD275-5CT 1 unit
EUR 6.65
Description: Ketoconazole KT 30 mcg

Ketoconazole KT 30 mcg
SD275-5VL 1 unit
EUR 11.84
Description: Ketoconazole KT 30 mcg

Ketoconazole KT 30 mcg
SD275-5X50DS 1 unit
EUR 6.5
Description: Ketoconazole KT 30 mcg

Plasminogen Receptor (KT) (PLGRKT) Antibody
20-abx318476
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Liquiport NF 100 KT. - EACH
PUM2680 EACH
EUR 1035.45

Cochranes molecular models 1 KT
Z184756-1KT 1KIT
EUR 26.9

Plasminogen Receptor (KT) (PLGRKT) Antibody
abx318476-100l 100 µl
EUR 250

Plasminogen Receptor (KT) (PLGRKT) Antibody
abx318476-50l 50 µl
EUR 162.5

(1S,3R)-GNE-502
T63045-10mg 10mg Ask for price
Description: (1S,3R)-GNE-502

(1S,3R)-GNE-502
T63045-1g 1g Ask for price
Description: (1S,3R)-GNE-502

(1S,3R)-GNE-502
T63045-1mg 1mg Ask for price
Description: (1S,3R)-GNE-502

(1S,3R)-GNE-502
T63045-50mg 50mg Ask for price
Description: (1S,3R)-GNE-502

(1S,3R)-GNE-502
T63045-5mg 5mg Ask for price
Description: (1S,3R)-GNE-502

Liquiport NF 1.100 KT.18RC - EACH
PUM2656 EACH
EUR 1167.75

Liquiport NF 1.300 KT.18RC - EACH
PUM2668 EACH
EUR 1478.25

Liquiport NF 300 KT.18RC - EACH
PUM2692 EACH
EUR 1251.45

KNF Liquiport NF 300 KT - EACH
PUM2694 EACH
EUR 1036.8

Cochranes molecular models 1 KT - 1KIT
Z119679-1KT 1KIT
EUR 33.78

HBVpol502, HBV polymerase (502 - 510)
5-01274 4 x 5mg Ask for price

Poly/Bed® 502 Resin
00552-500 500g
EUR 72
Description: 84-74-2

HAV VP1 (aa 502 - 605)
DAG3317 100 µg
EUR 972

hsa-miR-502-3p Primers
MPH01741 150 ul / 10 uM
EUR 145.2

hsa-miR-502-5p Primers
MPH01742 150 ul / 10 uM
EUR 145.2

Fish 11-keto Testosterone (KT) ELISA Kit
EK11227 96Т
EUR 799

Fish 11-keto Testosterone (KT) ELISA Kit
AE58425FI-48Tests 48 Tests
EUR 290
Description: Fish

Fish 11-keto Testosterone (KT) ELISA Kit
AE58425FI-96Tests 96 Tests
EUR 540
Description: Fish

11-KT( 11-keto Testosterone) ELISA Kit
ELK8908-48T 48T Ask for price
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with 11-KT protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to 11-KT. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of 11-KT in the samples is then determined by comparing the OD of the samples to the standard curve.

11-KT( 11-keto Testosterone) ELISA Kit
ELK8908-96T 96T Ask for price
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with 11-KT protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to 11-KT. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of 11-KT in the samples is then determined by comparing the OD of the samples to the standard curve.

Human 11-Ketotestosterone, 11-KT GENLISA ELISA
KBH5106 1 x 96 wells
EUR 286

KT 170 capacity 163L Cooled Incubator - EACH
INC1074 EACH
EUR 8752.58

KNF Liquiport NF 1.100 KT.18S - EACH
PUM2658 EACH
EUR 954.45

Human11-keto Testosterone (11-KT) ELISA Kit
NSL2276Hu 96 wells
EUR 468

B30C-4000-483OR-KT AF Systems Consumables
139928 Box of 1 Roll
EUR 563.88
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-2250-483OR-KT AF Systems Consumables
139929 Box of 1 Roll
EUR 415.4
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-1125-483OR-KT AF Systems Consumables
139930 Box of 1 Roll
EUR 274.35
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-4000-483BK-KT AF Systems Consumables
139931 Box of 1 Roll
EUR 563.88
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-2250-483BK-KT AF Systems Consumables
139932 Box of 1 Roll
EUR 415.4
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-1125-483BK-KT AF Systems Consumables
139933 Box of 1 Roll
EUR 274.35
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-4000-483GN-KT AF Systems Consumables
139934 Box of 1 Roll
EUR 563.88
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-2250-483GN-KT AF Systems Consumables
139935 Box of 1 Roll
EUR 415.4
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-1125-483GN-KT AF Systems Consumables
139936 Box of 1 Roll
EUR 274.35
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-4000-483BL-KT AF Systems Consumables
139937 Box of 1 Roll
EUR 563.88
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-2250-483BL-KT AF Systems Consumables
139938 Box of 1 Roll
EUR 415.4
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-1125-483BL-KT AF Systems Consumables
139939 Box of 1 Roll
EUR 274.35
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-4000-483RD-KT AF Systems Consumables
139940 Box of 1 Roll
EUR 563.88
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-2250-483RD-KT AF Systems Consumables
139941 Box of 1 Roll
EUR 415.4
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-1125-483RD-KT AF Systems Consumables
139942 Box of 1 Roll
EUR 274.35
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-4000-483YL-KT AF Systems Consumables
139943 Box of 1 Roll
EUR 563.88
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-3000-483YL-KT AF Systems Consumables
139944 Box of 1 Roll
EUR 473.22
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-2250-483YL-KT AF Systems Consumables
139945 Box of 1 Roll
EUR 415.4
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-1125-483YL-KT AF Systems Consumables
139946 Box of 1 Roll
EUR 274.35
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-4000-483WT-KT AF Systems Consumables
139947 Box of 1 Roll
EUR 563.88
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-3000-483WT-KT AF Systems Consumables
139948 Box of 1 Roll
EUR 473.22
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-2250-483WT-KT AF Systems Consumables
139949 Box of 1 Roll
EUR 415.4
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

B30C-1125-483WT-KT AF Systems Consumables
139950 Box of 1 Roll
EUR 274.35
Description: Description Dutch: ToughStripe-vloertape voor BBP35/BBP37/S3xxx/i3300-printers; Description French: Ruban de marquage au sol ToughStripe pour imprimantes BBP35/BBP37/S3xxx/i3300

Human Plasminogen Receptor (KT) (PLGRKT) ELISA Kit
abx539314-96tests 96 tests
EUR 687.5

Mouse Plasminogen Receptor (KT) (PLGRKT) ELISA Kit
abx539315-96tests 96 tests
EUR 687.5