Among the preclinical molecular imaging approaches, lately fluorine (19 F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community, due to the unique properties of fluorinated materials and the 19 F nucleus. Fluorine is an intrinsically sensitive nucleus for MRI-there is negligible endogenous 19 F in the body and, thus, no background signal which allows the detection of fluorinated materials as “hot spots” by combined 1 H/19 F MRI and renders fluorine-containing molecules as ideal tracers with high specificity.
In addition, perfluorocarbons are a family of compounds that exhibit a very high fluorine payload and are biochemically as well as physiologically inert. Perfluorocarbon nanoemulsions (PFCs) are well known to be readily taken up by immunocompetent cells, which can be exploited for the unequivocal identification of inflammatory foci by tracking the recruitment of PFC-loaded immune cells to affected tissues using 1 H/19 F MRI.
The required 19 F labeling of immune cells can be accomplished either ex vivo by PFC incubation of isolated endogenous immune cells followed by their re-injection or by intravenous application of PFCs for in situ uptake by circulating immune cells. With both approaches, inflamed tissues can unambiguously be detected via background-free 19 F signals due to trafficking of PFC-loaded immune cells to affected organs.
To extend 19 F MRI tracking beyond cells with phagocytic properties, the PFC surface can further be equipped with distinct ligands to generate specificity against epitopes and/or types of immune cells independent of phagocytosis. Recent developments also allow for concurrent detection of different PFCs with distinct spectral signatures allowing the simultaneous visualization of several targets, such as various immune cell subtypes labeled with these PFCs.
Since ligands and targets can easily be adapted to a variety of problems, this approach provides a general and versatile platform for inflammation imaging which will strongly extend the frontiers of molecular MRI. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease.
Nanomagnetic 50nm magnetic beads are available from Gentaur and Clemente associates.
 KT 5823 |
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B6673-.05 |
ApexBio |
50 µg |
EUR 76 |
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Description: MAPK Signaling|Protein Kinase G |
KT 5823 |
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B6673-.1 |
ApexBio |
100 µg |
EUR 120 |
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Description: MAPK Signaling|Protein Kinase G |
KT 5823 |
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B6673-.25 |
ApexBio |
250 µg |
EUR 249 |
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Description: protein kinase G inhibitor |
KT 5823 |
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B6673-.5 |
ApexBio |
500ug |
EUR 468 |
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Description: MAPK Signaling|Protein Kinase G |
 KT 5720 |
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B9002-.05 |
ApexBio |
50 µg |
EUR 101.6 |
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Description: MAPK Signaling|PKA |
KT 5720 |
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B9002-.1 |
ApexBio |
100 µg |
EUR 193.6 |
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Description: MAPK Signaling|PKA |
KT 5720 |
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B9002-.25 |
ApexBio |
250 µg |
EUR 459.2 |
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Description: MAPK Signaling|PKA |
KT 5720 |
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B9002-.5 |
ApexBio |
500 µg |
EUR 815.2 |
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Description: MAPK Signaling|PKA |
 KT-5720 |
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abx076628-250l |
Abbexa |
250 µl |
EUR 212.5 |
KT-5720 |
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abx076628-500l |
Abbexa |
500 µl |
EUR 487.5 |
KT 5823 |
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20-abx076629 |
Abbexa |
-
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 KT-5823 |
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abx076629-250l |
Abbexa |
250 µl |
EUR 168.75 |
KT-5823 |
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abx076629-500l |
Abbexa |
500 µl |
EUR 462.5 |
 KT-531 |
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HY-128436 |
MedChemExpress |
5mg |
EUR 498.93 |
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Description: KT-531 is a potent and selective inhibitor of HDAC6 with an IC50 of 8.5 nM. KT-531 exhibits strong inhibition against SUP-T11 cells with an IC50 of 0.42 μM. KT-531 can be used in study hematological cancers[1]. |
 KT-474 |
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HY-145483 |
MedChemExpress |
1 mg |
EUR 9415.73 |
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Description: KT-474 (KYM-001) is an orally active PROTAC IRAK4 degrader with antitumor activities[1]. KT-474 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
 NCT-502 |
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C5478-10 |
ApexBio |
10 mg |
EUR 145.6 |
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Description: Metabolism|Dehydrogenase |
NCT-502 |
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C5478-25 |
ApexBio |
25 mg |
EUR 328 |
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Description: Metabolism|Dehydrogenase |
NCT-502 |
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C5478-5 |
ApexBio |
5 mg |
EUR 80.8 |
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Description: Metabolism|Dehydrogenase |
 BMS-502 |
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HY-149874 |
MedChemExpress |
10 mg |
EUR 411.26 |
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Description: BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research[1]. |
 GNE-502 |
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HY-132294 |
MedChemExpress |
1 mg |
EUR 4166.73 |
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Description: GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1]. |
NCT-502 |
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HY-117240 |
MedChemExpress |
50mg |
EUR 333.34 |
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Description: NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1]. |
 NOSO-502 |
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HY-123922 |
MedChemExpress |
Get quote |
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Description: NOSO-502 is an inhibitor of bacterial translation. NOSO-502 exhibits inhibitory activity against Enterobacteriaceae. NOSO-502 has good safety and antibacterial properties[1]. |
NCT-502 |
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MBS3843211-5x100mg |
MyBiosource |
5x100mg |
EUR 2440 |
 KT-362 fumarate |
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MBS5777458-5mg |
MyBiosource |
5(mg |
EUR 915 |
KT-362 fumarate |
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MBS5777458-5x5mg |
MyBiosource |
5x5(mg |
EUR 3970 |
KT-362 fumarate |
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T27753-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
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Description: KT-362 fumarate |
KT-362 fumarate |
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T27753-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
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Description: KT-362 fumarate |
 WML-502-502-4S AF Systems Consumables |
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032525 |
BRADY NV |
Roll of 1000 Label(s) |
EUR 60.12 |
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Description: Description Dutch: LS 2000 & BradyMarker XC Plus Printer Labels; Description French: Etiquettes LS 2000 & BradyMarker XC Plus |
 WML-502-502-2S AF Systems Consumables |
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032531 |
BRADY NV |
Roll of 500 Label(s) |
EUR 46.96 |
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Description: Description Dutch: LS 2000 & BradyMarker XC Plus Printer Labels; Description French: Etiquettes LS 2000 & BradyMarker XC Plus |
 Biolipidure-502-Reagent |
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Biolipidure-502-10 |
AS ONE International |
10mL |
EUR 235.2 |
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Description: The Biolipidure-502 Reagent is a synthetic cationic polymer. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement |
Biolipidure-502-Reagent |
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Biolipidure-502-100 |
AS ONE International |
100mL |
EUR 1467.6 |
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Description: The Biolipidure-502 Reagent is a synthetic cationic polymer. Applications include: Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement |
 let-502 Antibody |
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CSB-PA310884XA01CXY-02mg |
Cusabio |
0.2mg |
Ask for price |
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Description: Recombinant Caenorhabditis elegans let-502 protein |
let-502 Antibody |
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CSB-PA310884XA01CXY-10mg |
Cusabio |
10mg |
Ask for price |
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Description: Recombinant Caenorhabditis elegans let-502 protein |
) Forchlorfenuron (KT-30, CPPU) |
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C7187-1000 |
ApexBio |
1g |
EUR 68 |
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Description: Others |
Forchlorfenuron (KT-30, CPPU) |
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C7187-500 |
ApexBio |
500mg |
EUR 40 |
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Description: Others |
) Forchlorfenuron (KT-30 CPPU) |
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MBS3610270-100mg |
MyBiosource |
100mg |
EUR 215 |
Forchlorfenuron (KT-30 CPPU) |
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MBS3610270-500mg |
MyBiosource |
500mg |
EUR 240 |
Forchlorfenuron (KT-30 CPPU) |
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MBS3610270-50mg |
MyBiosource |
50mg |
EUR 200 |
Forchlorfenuron (KT-30 CPPU) |
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MBS3610270-5x500mg |
MyBiosource |
5x500mg |
EUR 750 |
Forchlorfenuron (KT-30, CPPU) |
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MBS5751941-500mg |
MyBiosource |
500mg |
EUR 145 |
Forchlorfenuron (KT-30, CPPU) |
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MBS5751941-5x500mg |
MyBiosource |
5x500mg |
EUR 500 |
-GNE-502) (1S,3R)-GNE-502 |
|
HY-132294A |
MedChemExpress |
Get quote |
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Description: (1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC50 value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor[1]. |
) HBV polymerase (502-510) |
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MBS8246573-10mg |
MyBiosource |
10mg |
EUR 560 |
HBV polymerase (502-510) |
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MBS8246573-1mg |
MyBiosource |
1mg |
EUR 225 |
HBV polymerase (502-510) |
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MBS8246573-5mg |
MyBiosource |
5mg |
EUR 400 |
HBV polymerase (502-510) |
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MBS8246573-5x10mg |
MyBiosource |
5x10mg |
EUR 2435 |
(1S,3R)-GNE-502 |
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T63045-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
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Description: (1S,3R)-GNE-502 |
(1S,3R)-GNE-502 |
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T63045-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
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Description: (1S,3R)-GNE-502 |
 Mini Centrifuge BCMI-502 |
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BCMI-502 |
Biolab Scientific Ltd. |
Each |
Ask for price |
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Description: Designed with quick spin option, our product is a compact, easy to use, high speed mini centrifuge that delivers maximum productivity. Variable speed allows you to carry out complex as well as simple protocols. High speed accuracy, low maintenance and safety operating features make it an ideal choice for your separation processes. - Large radius rotor with 8 tube holes, centrifugal force is 1.5 times bigger than ordinary 6-hole rotor at the same rolling speed - The cover press-button is outward designed with start/stop function. Press the button, the cover will open automatically to 95°, which is very convenient for one-hand operation - The rotor is clip-on fixed. Very convenient for rotors exchanging yet fixed solid reliable - LED displays speed (MINI-10K+) and timing |
 Thermal Cycler BHTC-502 |
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BHTC-502 |
Biolab Scientific Ltd. |
Each |
Ask for price |
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Description: Thermal Cyclers have become an essential tool for DNA amplification, and are considered by many as the workhorse of the laboratory. It provides outstanding performance in a compact and user friendly design. Better performance, efficiency and faster optimization makes it a perfect choice for any laboratory. - New and unique appearance, the interface operation is simple and convenient, ultra-light ultra-thin - Hot lid can be switched on and off, and test tube temperature control mode and module temperature control mode can be choose to meet more different experimental requirements - MP-16 mini PCR can be used in vehicles - Can be quickly upgraded via U disk, convenient for instrument software update |
 Slide Printer BHTP-502 |
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BHTP-502 |
Biolab Scientific Ltd. |
Each |
Ask for price |
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Description: Slide printer eliminates the need for writing and labeling by directly printing on the slides with precision. - Laser printing and easy for maintaining. Capability of linking with the management system of the pathology department. Print online or off-line. The writing is clear and delicate, never wears out or fades, which meets the characteristicrequirements of keeping slides for long-term reference. No need for preheating, can be immediately used after starting up, safe and noiseless, and free of - Maintenance. |
 Flame Photometer BLFP-502 |
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BLFP-502 |
Biolab Scientific Ltd. |
Each |
Ask for price |
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Description: Flame Photometer is a simple quantitative analytical test based on the flame analysis. It is based on principle of measurement of the emitted light intensity of a metal due to the thermal energy provided by the flame source. The wavelength and the colour of the flame gives details about the element present in the sample, whereas the wavelength of emitted light is specific for specific elements. By direct absorption techniques, the absorbance of light due to the electrons excitation can be measured while the emitting radiation intensity is measured using the emission techniques. - A lot of new technology and new materials are adopted. Features such as LCD display, menu-type instruction operation, curve storage, flameout protector and outside printout are enabled by the application of top grade embedded mono-chip Computer circuit. - The instrument should be placed horizontally, avoiding direct sunshine radiation. - There is no disturbance of strong electromagnetic field or vibration. Fire extinguishing device should be equipped in the application field and good aeration should be guaranteed. - LCD display, menu-type instruction operation, curve storage, flameout protector and outside printout are enabled by the application of top grade embedded mono-chip. |
 Biological Microscope BMIC-502 |
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BMIC-502 |
Biolab Scientific Ltd. |
Each |
Ask for price |
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Description: Digital Biological Microscope is an optical microscope that is primarily designed to observes cells, tissues as well as other biological specimens. Magnification range anywhere from 10x – 1,000x or more by attaching multiple objective lenses. - Excellent optical function with seidentopf trinocular viewing head, inclined at 45°, 360° rotatable and backward quintuple nosepiece. Convenient operation and special design for viewing incubating cell tissue. Valid mould proof design. It can be used under the high temperature and high humidity environment. |
 Straw Micropipette BPIP-502 |
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BPIP-502 |
Biolab Scientific Ltd. |
Each |
Ask for price |
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Description: Single Channel Pipette is the new standard for microliter measurements. It is top of the line micropipette that is ergonomically designed and easily adjustable. They are commonly used in laboratory, research, chemistry, biology, forensic, pharmaceutical, and drug discovery labs to transfer small quantities of liquid. - Large central pipetting button and separate ejection function - True one-handed operation for both right-and left-handers - Completely autoclavable at 121°C (20min) - Volume-change protection |
 (PLGRKT) Antibody) Plasminogen Receptor (KT) (PLGRKT) Antibody |
|
abx318476-100l |
Abbexa |
100 µl |
EUR 250 |
Plasminogen Receptor (KT) (PLGRKT) Antibody |
|
20-abx318476 |
Abbexa |
-
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- 20 ug
- 50 ug
- 100 ug
- 200 ug
- 1 mg
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