Towards medical knowmetrics: representing and computing medical knowledge using semantic predications as the knowledge unit and the uncertainty as the knowledge context

In China, Prof. Hongzhou Zhao and Zeyuan Liu are the pioneers of the idea “knowledge unit” and “knowmetrics” for measuring knowledge. However, the definition on “computable knowledge object” stays controversial up to now in several fields. For instance, it’s outlined as (1) quantitative scientific idea in pure science and engineering, (2) knowledge level in the subject of training analysis, and (3) semantic predications, i.e., Subject-Predicate-Object (SPO) triples in biomedical fields. The Semantic MEDLINE Database (SemMedDB), a high-quality public repository of SPO triples extracted from medical literature, gives a primary knowledge infrastructure for measuring medical knowledge. In normal, the research of extracting SPO triples as computable knowledge unit from unstructured scientific textual content has been overwhelmingly specializing in scientific knowledge per se.

Since the SPO triples could be probably extracted from hypothetical, speculative statements and even conflicting and contradictory assertions, the knowledge standing (i.e., the uncertainty), which serves as an integral and crucial a part of scientific knowledge has been largely missed. This article goals to place ahead a framework for Medical Knowmetrics using the SPO triples as the knowledge unit and the uncertainty as the knowledge context. The lung most cancers publications dataset is used to validate the proposed framework. The uncertainty of medical knowledge and how its standing evolves over time not directly mirror the energy of competing knowledge claims, and the likelihood of certainty for a given SPO triple.

We attempt to focus on the new insights using the uncertainty-centric approaches to detect analysis fronts, and establish knowledge claims with excessive certainty degree, in an effort to enhance the efficacy of knowledge-driven resolution help. Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes is one in every of the most generally used cell-based fashions that resulted from the discovery of how non-embryonic stem cells might be differentiated into a number of cell sorts. In only one decade, iPSC-derived cardiomyocytes went from a analysis lab to widespread use in biomedical analysis and preclinical security analysis for medication and different chemical compounds.

Insulin: A Pacesetter for the Shape of Modern Biomedical Science and the Nobel Prize

The 100th anniversary of the discovery of insulin in Toronto in 1921 is a crucial second in medical and scientific historical past. The demonstration that an extract of canine pancreas reproducibly lowered blood glucose, initially in diabetic canines and then in people with sort 1 diabetes, was a medical breakthrough that modified the course of what was till then a largely deadly illness. The discovery of the “exercise” – quickly named “insulin” – was extensively celebrated, garnering a Nobel Prize for Banting and McLeod in 1923. Over the ensuing 100 years, analysis on insulin has superior on many fronts, producing insights which have remodeled our understanding of diabetes and our strategy to its therapy.

But it’s too usually unappreciated that analysis on insulin had one other consequence of far broader scientific significance, serving as a pacesetter and catalyst to bioscience analysis throughout many fields. Some of this was straight insulin-related, and like its discovery was additionally acknowledged by the Nobel Prize. Equally vital, nonetheless, was analysis stimulated by the discovery of insulin that has profoundly influenced biomedical analysis, generally additionally acknowledged by the Nobel Prize and generally with out this recognition, however maybe equally vital. In this paper, we evaluation a few of the most notable examples of each insulin-related and insulin-stimulated analysis as an instance the impression of this discovery on the course of contemporary bioscience.

Towards medical knowmetrics: representing and computing medical knowledge using semantic predications as the knowledge unit and the uncertainty as the knowledge context

Career Retrospective: Tom Johnson – Genetics, Genomics, Stress, Stochastic Variation and Aging

Here we mirror on the extremely influential profession of Thomas “Tom” E. Johnson and his contributions to gerontology. Tom is taken into account the father of genetic gerontology as a result of he proved the beforehand contentious notion that lifespan might be very considerably influenced by single genes. Tom went on to characterize the growing older course of holistically with genomics. Moreover, Tom’s laboratory made important and lasting discoveries demonstrating that the prevention and restore of somatic injury determines lifespan.

Finally, Tom discovered a solution to research the origins and penalties of stochastic elements of growing older, arguably uncovering the first strong biomarker and predictor of growing older. Johnson’s contributions kind the bedrock of a complete subfield in biology, and are additionally the basis of the present revolution in biomedical analysis that’s concentrating on the growing older processes to forestall age-related persistent ailments, from Alzheimer’s to most cancers. From easy experiments on growing older in nematode worms, a brand new biotechnology trade is rising.

Hen Blocker

CH23106 100 ml
EUR 362

EZBlock? (TBS) Blocking Buffer

2117-1000
EUR 212

EZBlock? (TBS) Blocking Buffer

2117-200
EUR 125

EZBlock? (PBS) Blocking Buffer

2128-1000
EUR 229

EZBlock? (PBS) Blocking Buffer

2128-200
EUR 137

TBS Blocking Buffer Pack

AR0143 200mL/pack
EUR 65

Blocking Buffer for ELISA

abx090807-500ml 500 ml
EUR 384
  • Shipped within 5-10 working days.

Neptune Blocking Buffer-BB2

KF17338 500 ml
EUR 244

SynBlock Blocking Buffer-BB3

KF17339 500 ml
EUR 244

Blocking Buffer, 10X, 250ML

X109-250ML 250ML
EUR 359

Blocking Buffer, 10X, 25ML

X109-25ML 25ML
EUR 122

Permeabilization and Blocking Buffer (5X)

22017 100mL
EUR 149
Description: Minimum order quantity: 1 unit of 100mL

TrueBlack WB Blocking Buffer Kit

23013 1kit
EUR 347
Description: Minimum order quantity: 1 unit of 1kit

TrueBlack WB Blocking Buffer Kit

23013-T 1kit
EUR 125
Description: Minimum order quantity: 1 unit of 1kit

EZBlock? T20 (TBS) Blocking Buffer

2140-1000
EUR 218

EZBlock? T20 (TBS) Blocking Buffer

2140-200
EUR 120

EZBlock? T20 (PBS) Blocking Buffer

2143-1000
EUR 218

EZBlock? T20 (PBS) Blocking Buffer

2143-200
EUR 120

Blocking Buffer and Coating Stabilizer

abx090811-1000ml 1000 ml
EUR 523
  • Shipped within 5-10 working days.

3 Blocking Buffer Sample Pack

KF17340 3 x 100 ml
EUR 205

West-Ezier Super Blocking Buffer

W3700-010 100ml
EUR 97

West-Ezier Super Blocking Buffer

W3700-050 500ml
EUR 165

West-Ezier Super Blocking Buffer

W3700-100 1L
EUR 246

PBS Blocking buffer with BSA

SB0626 1pk, 1L
EUR 83.93
  • Product category: Biochemicals/Biological Buffers/Common Buffers

TBS blocking buffer with BSA

SD8113 1pk, 1L
EUR 83.93
  • Product category: Biochemicals/Biological Buffers/Common Buffers

Active Blocker 2

abx090802-01g 0.1 g
EUR 495
  • Shipped within 5-10 working days.

Active Blocker 3

abx090803-01g 0.1 g
EUR 411
  • Shipped within 5-10 working days.

Active Blocker 1

abx090804-01g 0.1 g
EUR 599
  • Shipped within 5-10 working days.

Bax channel blocker

A4459-10 10 mg
EUR 340
Description: IC50: 0.52 ?M in Bax assayBax channel blocker is an inhibitor of Bax-mediated mitochondrial cytochrome c release.

Bax channel blocker

A4459-50 50 mg
EUR 1276
Description: IC50: 0.52 ?M in Bax assayBax channel blocker is an inhibitor of Bax-mediated mitochondrial cytochrome c release.

BCTC (TRPV1 blocker)

SIH-307-10MG 10 mg
EUR 202
  • BCTC is an inhibitor of capsaicin- and acid-mediated currents at rat VR1. Thus it has effects on acute, inflammatory and neuropathic pain in rats (1, 2).
Description: The substance BCTC is a trpv1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 40 mM in ethanol.

BCTC (TRPV1 blocker)

SIH-307-50MG 50 mg
EUR 375
  • BCTC is an inhibitor of capsaicin- and acid-mediated currents at rat VR1. Thus it has effects on acute, inflammatory and neuropathic pain in rats (1, 2).
Description: The substance BCTC is a trpv1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 40 mM in ethanol.

Casein-based PBS Blocking Buffer Pack

AR0182 500mL/Pack
EUR 70

Casein-based TBS Blocking Buffer Pack

AR0183 500mL/Pack
EUR 70

EZBlock? Blocking Buffer and Signal Enhancer

M4104-100
EUR 153

EZBlock? Blocking Buffer and Signal Enhancer

M4104-500
EUR 359

Blocking Buffer for ICC and IHC

SF40011 10 ml
EUR 128

Universal Casein Diluent/Blocker

85R-108 250 ml
EUR 230
Description: Ready-to-use biotin free reagent applicable for blocking ELISA plates

Cav 2.2 blocker 1

HY-119373 10mg
EUR 681

M2 ion channel blocker

HY-75867 100mg
EUR 317

Fc Receptor Blocker, 60ml

NB309 60 ml
EUR 833

Fc Receptor Blocker, 15ml

NB309-15 15 ml
EUR 392

Fc Receptor Blocker, 30ml

NB309-30 30 ml
EUR 508

Fc Receptor Blocker, 5ml

NB309-5S 5 ml
EUR 188

Cyclopamine (Hedgehog signaling blocker)

SIH-226-1MG 1 mg
EUR 135
  • Cyclopamine is a hedgehog signaling pathway inhibitor that influences the balance between the active and inactive forms of the Smoothened protein (1). It is being investigated as a treatment agent in basal cell carcinoma, medulloblastoma and rhabdomy
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Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol.

Cyclopamine (Hedgehog signaling blocker)

SIH-226-5MG 5 mg
EUR 345
  • Cyclopamine is a hedgehog signaling pathway inhibitor that influences the balance between the active and inactive forms of the Smoothened protein (1). It is being investigated as a treatment agent in basal cell carcinoma, medulloblastoma and rhabdomy
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Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol.

A-967079 (TRPA1 blocker)

SIH-301-10MG 10 mg
EUR 179
  • A-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine??uorine subs
  • Show more
Description: The substance A-967079 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in DMSO (25 mg/ml).

A-967079 (TRPA1 blocker)

SIH-301-50MG 50 mg
EUR 490
  • A-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine??uorine subs
  • Show more
Description: The substance A-967079 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in DMSO (25 mg/ml).

Astemizole (Herg channel blocker)

SIH-302-10MG 10 mg
EUR 133
  • Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, an
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Description: The substance Astemizole is a herg channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 25 mM in ethanol.

Astemizole (Herg channel blocker)

SIH-302-50MG 50 mg
EUR 329
  • Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, an
  • Show more
Description: The substance Astemizole is a herg channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 25 mM in ethanol.

HC-030031 (TRPA1 blocker)

SIH-303-10MG 10 mg
EUR 144
  • Selective TRPA1 channel blocker that antagonizes AITC-and formalin-evoked calcium influx. Doe not block currents mediated by TRPV1, V3, V4, hERG or Nav1.2 channels (1-2).
Description: The substance HC-030031 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO.

HC-030031 (TRPA1 blocker)

SIH-303-50MG 50 mg
EUR 386
  • Selective TRPA1 channel blocker that antagonizes AITC-and formalin-evoked calcium influx. Doe not block currents mediated by TRPV1, V3, V4, hERG or Nav1.2 channels (1-2).
Description: The substance HC-030031 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO.

A-803467 (NaV1.8 blocker)

SIH-304-10MG 10 mg
EUR 144
  • A selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pai
  • Show more
Description: The substance A-803467 is a nav1.8 blocker. It is synthetically produced and has a purity of >98%. The pure substance is beige solid which is soluble to 100 mM in DMSO and to 25 mM in ethanol.

A-803467 (NaV1.8 blocker)

SIH-304-50MG 50 mg
EUR 386
  • A selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pai
  • Show more
Description: The substance A-803467 is a nav1.8 blocker. It is synthetically produced and has a purity of >98%. The pure substance is beige solid which is soluble to 100 mM in DMSO and to 25 mM in ethanol.

Pyr3 (TRPC3 Channel blocker)

SIH-306-10MG 10 mg
EUR 202
  • Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor o
  • Show more
Description: The substance Pyr3 is a trpc3 channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO.

Pyr3 (TRPC3 Channel blocker)

SIH-306-50MG 50 mg
EUR 577
  • Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor o
  • Show more
Description: The substance Pyr3 is a trpc3 channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO.

AP-18 (TRPA1 blocker)

SIH-310-10MG 10 mg
EUR 163
  • AP-18 is a reversible TRPA1 channel blocker. They exhibit fibroblast-like morphology, slow growth and contact inhibition (1).
Description: The substance AP-18 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 100 mM in ethanol.

AP-18 (TRPA1 blocker)

SIH-310-50MG 50 mg
EUR 479
  • AP-18 is a reversible TRPA1 channel blocker. They exhibit fibroblast-like morphology, slow growth and contact inhibition (1).
Description: The substance AP-18 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 100 mM in ethanol.

Dofetilide (Herg channel blocker)

SIH-311-10MG 10 mg
EUR 175
  • Dofetilide is a class III antiarrhythnic agent (1). It works by selectively blocking the rapid component of the delayed rectifier outward potassium current (2).
Description: The substance Dofetilide is a herg channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO.

Dofetilide (Herg channel blocker)

SIH-311-50MG 50 mg
EUR 501
  • Dofetilide is a class III antiarrhythnic agent (1). It works by selectively blocking the rapid component of the delayed rectifier outward potassium current (2).
Description: The substance Dofetilide is a herg channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO.

2-APB (TRP blocker)

SIH-316-250MG 250 mg
EUR 155
  • 2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions
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Description: The substance 2-APB is a trp blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 10 mM in ethanol.

2-APB (TRP blocker)

SIH-316-50MG 50 mg
EUR 98
  • 2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions
  • Show more
Description: The substance 2-APB is a trp blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 10 mM in ethanol.

SB-366791 (TRPV1 blocker)

SIH-321-10MG 10 mg
EUR 179
  • A potent and selective vanilloid receptor (TRPV1) antagonist. An effective antagonist of hTRPV1 when stimulated by capsaicin, acid, or noxious heat.
Description: The substance SB-366791 is a trpv1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 10 mM in ethanol and to 100 mM in DMSO.

SB-366791 (TRPV1 blocker)

SIH-321-50MG 50 mg
EUR 582
  • A potent and selective vanilloid receptor (TRPV1) antagonist. An effective antagonist of hTRPV1 when stimulated by capsaicin, acid, or noxious heat.
Description: The substance SB-366791 is a trpv1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 10 mM in ethanol and to 100 mM in DMSO.

Blocking Buffer for Lateral Flow (PBS based)

abx090808-500ml 500 ml
EUR 384
  • Shipped within 5-10 working days.

T-Pro Fast Blocking Buffer (in PBS)

JK92-W001 500ml/BT
EUR 187

T-Pro Fast Blocking Buffer (in TBS)

JK92-W002 500ml/BT
EUR 187

PBS Blocking buffer with non fat milk

SB0625 1pk, 1L
EUR 67.4
  • Product category: Biochemicals/Biological Buffers/Common Buffers

Universal IHC Diluent/Blocker/Stabilizer

85R-1021 1 liter
EUR 692
Description: Universal Diluent/Blocker/Stabilizer for use in IHC

Azide Free Fc Rreceptor Blocker

NB335 30 ml
EUR 543

U-74389G (Lipid peroxidation blocker)

SIH-205-100MG 100 mg
EUR 174
  • U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It prevents organ damage in intestinal cold storage, preservation and reperfusion injury (1-4).
Description: The substance U-74389G is a lipid peroxidation blocker. It is synthetically produced and has a purity of >99%. The pure substance is white solid which is soluble in 25 mg/ml DMSO, and in 20 mg/ml in ethanol; Insoluble in water.

U-74389G (Lipid peroxidation blocker)

SIH-205-500MG 500 mg
EUR 582
  • U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It prevents organ damage in intestinal cold storage, preservation and reperfusion injury (1-4).
Description: The substance U-74389G is a lipid peroxidation blocker. It is synthetically produced and has a purity of >99%. The pure substance is white solid which is soluble in 25 mg/ml DMSO, and in 20 mg/ml in ethanol; Insoluble in water.

SKF-96365 (TRPC channel blocker)

SIH-305-25MG 25 mg
EUR 444
  • SKF-96365 is a selective inhibitor of receptor mediated Ca2+ entry and voltage-gated Ca2+ entry (1). It has also been shown o inhibit cytochrome P-450 mediated reactions (1,2), and reversibly activates non-selective cation channels in human endotherl
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Description: The substance SKF-96365 is a trpc channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in water.

SKF-96365 (TRPC channel blocker)

SIH-305-5MG 5 mg
EUR 159
  • SKF-96365 is a selective inhibitor of receptor mediated Ca2+ entry and voltage-gated Ca2+ entry (1). It has also been shown o inhibit cytochrome P-450 mediated reactions (1,2), and reversibly activates non-selective cation channels in human endotherl
  • Show more
Description: The substance SKF-96365 is a trpc channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in water.

E-4031 (Herg channel blocker)

SIH-317-10MG 10 mg
EUR 221
  • E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).
Description: The substance E-4031 is a herg channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in water (100 mg/ml) and warm DMSO (25 mg/ml).

E-4031 (Herg channel blocker)

SIH-317-50MG 50 mg
EUR 601
  • E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).
Description: The substance E-4031 is a herg channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in water (100 mg/ml) and warm DMSO (25 mg/ml).

Vinblastine sulfate (Cell cycle blocker)

SIH-407-25MG 25 mg
EUR 305
  • Vinblastine sulfate is used clinically as a cancer chemotherapeutic agent. It disrupts normal microtubule assembly. Vinblastine also inhibits autophagy by obstructing autophagosome maturation and by stopping the fusion event of autophagosomes with ly
  • Show more
Description: The substance Vinblastine sulfate is a cell cycle blocker. It is synthetically produced and has a purity of ?98%. The pure substance is white powder. which is soluble in DMSO, methanol or water (25 mg/ml)..

Vinblastine sulfate (Cell cycle blocker)

SIH-407-5MG 5 mg
EUR 126
  • Vinblastine sulfate is used clinically as a cancer chemotherapeutic agent. It disrupts normal microtubule assembly. Vinblastine also inhibits autophagy by obstructing autophagosome maturation and by stopping the fusion event of autophagosomes with ly
  • Show more
Description: The substance Vinblastine sulfate is a cell cycle blocker. It is synthetically produced and has a purity of ?98%. The pure substance is white powder. which is soluble in DMSO, methanol or water (25 mg/ml)..

ELISA Plate Blocking Buffer concentrate (10X) BSA-based

80060 50 ml
EUR 202

ChonBlock Blocking/Sample Dilution ELISA Buffer, 100 ml

9068 100 ml
EUR 129.75
Description: ChonBlock Blocking/Sample Dilution ELISA Buffer

T-Pro Protein Free Blocking Buffer (in PBS)

JK92-W003 500ml/BT
EUR 187

T-Pro Protein Free Blocking Buffer (in TBS)

JK92-W004 500ml/BT
EUR 187

West-Ezier Super Blocking Buffer for Phospho Antibody

W3701-010 100ml
EUR 131

West-Ezier Super Blocking Buffer for Phospho Antibody

W3701-050 500ml
EUR 188

West-Ezier Super Blocking Buffer for Phospho Antibody

W3701-100 1L
EUR 280

Enhanced Universal IHC Diluent/Blocker/Stabilizer

85R-1021E 100 ml
EUR 187
Description: Enhanced Universal Diluent/Blocker/Stabilizer for use in IHC

N-type calcium channel blocker-1

HY-100310 5mg
EUR 2120

Azide Free Fc Receptor Blocker NEW

NB335-60 60 ml
EUR 856

Nifedipine (L-type Ca channel blocker)

SIH-309-1G 1 g
EUR 110
  • Nifedipine is a dihydropyridine calcium channel blocker. It is used mainly as an antianginal, and hypertensive (1), but has other uses such as Raynaud's phenomenon (2), premature labor, and painful spasms of the esophagus.
Description: The substance Nifedipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble to 100 mM in DMSO.

Nifedipine (L-type Ca channel blocker)

SIH-309-5G 5 g
EUR 209
  • Nifedipine is a dihydropyridine calcium channel blocker. It is used mainly as an antianginal, and hypertensive (1), but has other uses such as Raynaud's phenomenon (2), premature labor, and painful spasms of the esophagus.
Description: The substance Nifedipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble to 100 mM in DMSO.

KB-R7943 mesylate (TRPC channel blocker)

SIH-312-10MG 10 mg
EUR 202
  • KN-R9743 mesylate is a potent selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger. It also inhibits the mitochondrial Ca2+ uniporter. It does not affect Na+ dependent transport systems or ionotropic glutamate receptors.
Description: The substance KB-R7943 mesylate is a trpc channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO.

KB-R7943 mesylate (TRPC channel blocker)

SIH-312-50MG 50 mg
EUR 612
  • KN-R9743 mesylate is a potent selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger. It also inhibits the mitochondrial Ca2+ uniporter. It does not affect Na+ dependent transport systems or ionotropic glutamate receptors.
Description: The substance KB-R7943 mesylate is a trpc channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO.

Isradipine (L-type Ca channel blocker)

SIH-314-10MG 10 mg
EUR 142
  • Isradipine is a calcium channel blocker of the dihydropyridine class. It is usually used in the treatment of high blood pressure because of its anti-hypertensive properties in vivo (1). Recent studies suggest a potential use for Parkinson's disease (
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Description: The substance Isradipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow crystalline solid which is soluble to 50 mM in DMSO and to 20 mM in ethanol.

Isradipine (L-type Ca channel blocker)

SIH-314-50MG 50 mg
EUR 375
  • Isradipine is a calcium channel blocker of the dihydropyridine class. It is usually used in the treatment of high blood pressure because of its anti-hypertensive properties in vivo (1). Recent studies suggest a potential use for Parkinson's disease (
  • Show more
Description: The substance Isradipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow crystalline solid which is soluble to 50 mM in DMSO and to 20 mM in ethanol.

Amlodipine (L-type Ca channel blocker)

SIH-315-250MG 250 mg
EUR 213
  • Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure.
Description: The substance Amlodipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 10 mM in water.

Amlodipine (L-type Ca channel blocker)

SIH-315-50MG 50 mg
EUR 133
  • Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure.
Description: The substance Amlodipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 10 mM in water.

Nitrendipine (L-type Ca channel blocker)

SIH-320-250MG 250 mg
EUR 455
  • Nitrendipine is a dihydropyridine calcium channel blocker. It does so by binding effectively with the L-type calcium channels in smooth muscles thereby inactivating it and reducing the influx of calcium.
Description: The substance Nitrendipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow crystalline solid which is soluble to 25 mM in ethanol and to 50 mM in DMSO.

Nitrendipine (L-type Ca channel blocker)

SIH-320-50MG 50 mg
EUR 159
  • Nitrendipine is a dihydropyridine calcium channel blocker. It does so by binding effectively with the L-type calcium channels in smooth muscles thereby inactivating it and reducing the influx of calcium.
Description: The substance Nitrendipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow crystalline solid which is soluble to 25 mM in ethanol and to 50 mM in DMSO.

Felodipine (L-type Ca channel blocker)

SIH-323-10MG 10 mg
EUR 131
  • Felodipine is an L-type Ca2+ channel blocker (1). In isolated rat ventricular myocytes, using a whole-cell patch-clamp technique, it displays a Ki of 11 nM (2). It is a clinically useful antihypertensive agent (3) which attenuates the hypertrophic ef
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Description: The substance Felodipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is light yellow solid which is soluble to 100 mM in ethanol and to 100 mM in DMSO.

Felodipine (L-type Ca channel blocker)

SIH-323-50MG 50 mg
EUR 294
  • Felodipine is an L-type Ca2+ channel blocker (1). In isolated rat ventricular myocytes, using a whole-cell patch-clamp technique, it displays a Ki of 11 nM (2). It is a clinically useful antihypertensive agent (3) which attenuates the hypertrophic ef
  • Show more
Description: The substance Felodipine is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is light yellow solid which is soluble to 100 mM in ethanol and to 100 mM in DMSO.

Fixation Buffer

22015 100mL
EUR 149
Description: Minimum order quantity: 1 unit of 100mL

Permeabilization Buffer

22016 100mL
EUR 149
Description: Minimum order quantity: 1 unit of 100mL

RIPA Buffer

2114-100
EUR 158

RIPA Buffer

2114-500
EUR 463

Dilution Buffer

1066-100
EUR 153

Dilution Buffer

1066-400
EUR 262

Wash Buffer

1210-200
EUR 196

Wash Buffer

abx098952-20ml 20 ml
EUR 91
  • Shipped within 5-7 working days.

Coating Buffer

abx098970-1vial 1 vial
EUR 154
  • Shipped within 5-7 working days.

Lysis Buffer

abx098984-LysisBuffer120ml Lysis Buffer 1 (20 ml)
EUR 154
  • Shipped within 5-7 working days.

Lysis Buffer

abx098984-LysisBuffer3100ml Lysis Buffer 3 (100ml)
EUR 230
  • Shipped within 5-7 working days.

Lysis Buffer

abx098984-LysisBuffer420ml Lysis Buffer 4 (20 ml)
EUR 154
  • Shipped within 5-7 working days.

Tricine buffer

20-abx082551
  • EUR 217.00
  • EUR 189.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

Binding Buffer

BB10X-50ML 50 ML
EUR 113.7

Binding Buffer

abx290019-50ml 50 ml
EUR 230
  • Shipped within 3-5 working days.

Wash Buffer

abx293002-30ml 30 ml
EUR 105
  • Shipped within 5-10 working days.

Wash Buffer

KF17356 500 ml
EUR 179

PBS Buffer

RM00012 2L
EUR 102

ADA buffer

AD0003 25g
EUR 64.79
  • Product category: Biochemicals/Biological Buffers/Common Buffers

10xTaq Buffer

PCRB60 4x1.5ml, 6ml
EUR 58.7
  • Product category: PCR Related/PCR Buffers

West-Ez Blocking Buffer, 1 % Casein for Western Blot

W3720-050 500ml
EUR 120

West-Ez Blocking Buffer, 1 % Casein for Western Blot

W3720-100 2x500ml
EUR 147

10X Tris-Glycine Native Buffer (Transfer buffer)

T8052-050 500ml
EUR 80

10X Tris-Glycine Native Buffer (Transfer buffer)

T8052-100 2X500ml
EUR 104

10X Tris-Glycine Native Buffer (Transfer buffer)

T8052-101 1L
EUR 95

10X Tris-Glycine Native Buffer (Transfer buffer)

T8052-200 4X500ml
EUR 128

10X Tris-Glycine Native Buffer (Transfer buffer)

T8052-201 2X1L
EUR 128

10X Tris-Glycine Native Buffer (Transfer buffer)

T8052-401 4X1L
EUR 165

TT Buffer (Tris-Tricine buffer) Primix powder

TD8133 1PK, 10L
EUR 76.1
  • Product category: Biochemicals/Biological Buffers/Common Buffers

Antibody/Antigen Conjugate Diluent/Blocker (Poly-HRP)

85R-111 250 ml
EUR 201
Description: Diluent buffer/blocker for use in Poly-HRP enhanced enzymatic labelling of antibodies and antigens

Fc Receptor Blocker; 4X Concentrate, 15ml NEW

NB309-4X-15 15 ml of 4X
EUR 775

Verapamil HCl (L-type Ca channel blocker)

SIH-308-1G 1 g
EUR 98
  • Verapamil is an L-type calcium channel blocker of the phenylalkylamine class. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and cluster headaches. Its mechanism is to block voltage-dependent calcium channels
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Description: The substance Verapamil HCl is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in ethanol and to 50 mM in water.

Verapamil HCl (L-type Ca channel blocker)

SIH-308-5G 5 g
EUR 165
  • Verapamil is an L-type calcium channel blocker of the phenylalkylamine class. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and cluster headaches. Its mechanism is to block voltage-dependent calcium channels
  • Show more
Description: The substance Verapamil HCl is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in ethanol and to 50 mM in water.

Nicardipine HCl (L-type Ca channel blocker)

SIH-313-250MG 250 mg
EUR 168
  • Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hyptertension and Raynaud's phenomenon. Its mechanism of acion is to inhibit the transmembrane influx of calci
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Description: The substance Nicardipine HCl is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble in DMSO (1 mg/ml), ethanol:water 25:75-70:30, propylene glycol, or methanol; slightly soluble in acetone, 100% ethanol, chloroform and water..

Nicardipine HCl (L-type Ca channel blocker)

SIH-313-50MG 50 mg
EUR 116
  • Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hyptertension and Raynaud's phenomenon. Its mechanism of acion is to inhibit the transmembrane influx of calci
  • Show more
Description: The substance Nicardipine HCl is a l-type ca channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble in DMSO (1 mg/ml), ethanol:water 25:75-70:30, propylene glycol, or methanol; slightly soluble in acetone, 100% ethanol, chloroform and water..

(R, S)-Niguldipine HCl (Ca2+ channel blocker)

SIH-319-10MG 10 mg
EUR 142
  • Niguldipine is a calcium channel blocker and an a1-adrenergic receptor antagonist.
Description: The substance (R, S)-Niguldipine HCl is a ca2+ channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble to 10 mM in water.

(R, S)-Niguldipine HCl (Ca2+ channel blocker)

SIH-319-50MG 50 mg
EUR 370
  • Niguldipine is a calcium channel blocker and an a1-adrenergic receptor antagonist.
Description: The substance (R, S)-Niguldipine HCl is a ca2+ channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble to 10 mM in water.

West-Ez Blocking Buffer, 3 % IgG Free-BSA in TBST

W3710-010 100ml
EUR 93

West-Ez Blocking Buffer, 3 % IgG Free-BSA in TBST

W3710-050 500ml
EUR 138

West-Ez Blocking Buffer, 3 % IgG Free-BSA in TBST

W3710-100 1L
EUR 182

West-Ezier Rapid Blocking Buffer, Ready-to-use, 5 Min

W3871-050 500ml
EUR 192

IgE Dilution Buffer

3009 1 mg/ml x 10 ml
EUR 80.45
Description: IgE Dilution Buffer

Here we concentrate on the early discoveries which have impressed 1000’s of researchers throughout the world to check growing older, and we acknowledge the wider significance of the creation of a subject that has the potential to remodel human well being. Intense X-rays obtainable at highly effective synchrotron beamlines present macromolecular crystallographers with an incomparable device for investigating organic phenomena on an atomic scale.

The ensuing insights into the mechanism’s underlying organic processes have performed a necessary function and formed biomedical sciences throughout the final 30 years, thought of the “golden age” of structural biology. In this evaluation, we analyze chosen facets of the impression of synchrotron radiation on structural biology. Synchrotron beamlines have been used to find out over 70% of all macromolecular constructions deposited into the Protein Data Bank (PDB).